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1,2,3,4,7,8-hexachlorodibenzodioxin

structure given in first source

Also Known As:

1,2,3,4,7,8-hexachlorodibenzo-p-dioxin; 123478-HxCDD; Dibenzo(b,e)(1,4)dioxin, 1,2,3,4,7,8-hexachloro-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Dioxins and Dioxin-like Compounds: 5
  - Dioxins: 1199
    - Polychlorinated Dibenzodioxins: 2278
      - 1,2,3,4,7,8-hexachlorodibenzodioxin: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Polychlorinated Dibenzodioxins: 2278
      - 1,2,3,4,7,8-hexachlorodibenzodioxin: 1

Experts

1.	Croutch, Claire R: 1 article (05/2005)
2.	Lebofsky, Margitta: 1 article (05/2005)
3.	Rozman, Karl K: 1 article (05/2005)
4.	Schramm, Karl-Werner: 1 article (05/2005)
5.	Terranova, Paul F: 1 article (05/2005)

Related Diseases

1.

Body Weight (Weight, Body)

05/01/2005 - "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD) alter body weight by decreasing insulin-like growth factor I (IGF-I) signaling."
05/01/2005 - "We investigated the effects of steady-state levels of TCDD (loading dose rates of 0.0125, 0.05, 0.2, 0.8, and 3.2 microg/kg) or approximately isoeffective dose rates of 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD) (loading dose rates of 0.3125, 1.25, 5, 20, and 80 microg/kg) on body weight, phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression and activity, and circulating concentrations of insulin, glucose, and insulin-like growth factor-I (IGF-I), and expression of hepatic phosphorylated AMP kinase-alpha (p-AMPK) protein in female Sprague-Dawley rats (approximately 250 gm) at 2, 4, 8, 16, 32, 64, and 128 days after commencement of treatment. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Phosphoenolpyruvate
4.	Insulin-Like Growth Factor I (IGF-1)
5.	Insulin (Novolin)
6.	Glucose (Dextrose)
7.	Adenylate Kinase
8.	Polychlorinated Dibenzodioxins (TCDD)
9.	1,2,3,6,7,8-hexachlorodibenzodioxin