catalpol

12/15/2022 - "Altogether, we demonstrate the potential of Catalpol as a novel treatment agent against cartilage matrix degradation, oxidative stress, and inflammation in OA."
02/07/2023 - "The overall objective of this study was to investigate the mechanism of inflammation on chondrocyte injury and the protective effect of catalpol on chondrocytes in an inflammatory environment. "
12/01/2021 - "From the overall results, this study displayed that catalpol exerted a beneficial effect on CORT-induced depressive-like behavior in mice possibly via the inhibition of hypothalamus-pituitary-adrenal (HPA) axis hyperactivity, central inflammation and oxidative damage at least partially through dual regulation of NF-κB and Nrf2."
10/01/2021 - "In short, this study indicated that catalpol could ameliorate endothelial dysfunction and inflammation via suppression of RAGE/RhoA/ROCK pathway, hereby delaying the progression of DN."
02/01/2018 - "The present study demonstrated the inhibitory effects exerted by catalpol on CNV and inflammation within alkali‑burned rat models. "

09/15/2018 - "In this study, we tested whether catalpol has the potential to improve insulin sensitivity by augmenting myogenesis. "
10/01/2020 - "Catalpol improves insulin sensitivity in skeletal muscle. "
03/01/2016 - "Our results showed that catalpol could significantly improve the insulin resistance, decrease the serum concentrations of INS, GSP, TG, and TC. "
01/01/2018 - "Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway."
11/27/2015 - "Catalpol ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by suppressing the JNK and NF-κB pathways."

12/01/2019 - "Repeated treatments with catalpol improved neurological score and significantly enhanced neuronal cell activity, then promote axonal regeneration after stroke. "
09/01/2014 - "The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P < 0.05 or P < 0.01). "
11/01/2020 - "Catalpol is the main active component of the radix of Rehmannia glutinosa Libosch, and it exhibits potential pleiotropic protective effects in many brain-related diseases, including stroke. "
09/15/2016 - "Following stroke, Catalpol improved the neuroethology deficit, increased the cerebral blood flow (CBF) of infarcted brain and upregulated EPO and EPOR. "
07/01/2019 - "This study aimed to investigate whether catalpol could affect miR-124 to regulate PI3K/AKT/mTOR pathway, promoting axonal growth in stroke rats. "

01/01/2015 - "Catalpol: a potential therapeutic for neurodegenerative diseases."
01/01/2016 - "The results of the present study indicate that catalpol may be a potential drug for the treatment of neurodegenerative diseases such as AD."
06/01/2008 - "Catalpol may be a potential anti-aging agent and worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's and Parkinson's diseases."
11/01/2012 - "Catalpol is a Chinese herb ingredient with potential for the treatment of neurodegenerative disorders. "
03/01/2009 - "The current results suggest that catalpol is a potential agent for the prevention of neurons apoptosis by regulating NO and iNOS increase in ERK-mediated neurodegenerative disorders."

12/15/2005 - "The neuroprotective efficacy of catalpol became more evident when the doses of catalpol were increased to 5 and 10mg/kg. In addition, it was exciting that the significant neuroprotection by catalpol was also evident when catalpol was applied up to 3 h after ischemia. "
12/17/2004 - "The neuroprotective efficacy of catalpol became more evident at the doses of 5 and 10 mg/kg. Of great importance were the findings that the neuroprotective efficacy of catalpol still could be seen even when the treatment was delayed 3 h and when the observational period was lasted out 35 days after ischemia. "
12/15/2005 - "But the neuroprotective efficacy of catalpol became weak when catalpol was given at 6h after ischemia. "
07/01/2019 - "Catalpol may improve axonal growth via regulating miR-124 regulated PI3K/AKT/mTOR pathway in neurons after ischemia."
01/01/2016 - "Taken together, these results suggest that catalpol protects PreOLs against ischemia-induced oxidative injury through ERK1/2 signaling pathway. "