fibroblast-derived tumor cytotoxic factor

isolated from human embryonic lung fibroblasts; cytotoxic against various human & mouse tumor cells; very similar and may be identical to the hepatocyte growth factor; has 2 chains, alpha & beta, MW 76-80 kDa; has been sequenced

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Sarcoma 180 01/01/1993 - "This factor, termed F-TCF, is moderately cytotoxic in human tumor cell lines (KB, MCF-7, BG-1) and is very cytotoxic in mouse tumor cell lines (Sarcoma 180, Meth A sarcoma, P388). " 05/01/1991 - "F-TCF showed moderate cytotoxicity on human tumor cell lines KB, BG-1, MCF-7 and Hs913 T, and strong cytotoxicity on mouse tumor cell lines Sarcoma 180, Meth A sarcoma and P388. " 07/16/1990 - "The fibroblast-derived tumor cytotoxic factor (F-TCF) has a cytotoxic activity to Sarcoma 180 and a cytostatic and degenerative activities to KB cells. "
2.	Sarcoma (Soft Tissue Sarcoma) 01/01/1993 - "This factor, termed F-TCF, is moderately cytotoxic in human tumor cell lines (KB, MCF-7, BG-1) and is very cytotoxic in mouse tumor cell lines (Sarcoma 180, Meth A sarcoma, P388). " 05/01/1991 - "F-TCF showed moderate cytotoxicity on human tumor cell lines KB, BG-1, MCF-7 and Hs913 T, and strong cytotoxicity on mouse tumor cell lines Sarcoma 180, Meth A sarcoma and P388. "
3.	Neoplasms (Cancer) 05/01/1991 - "These biological functions suggest that F-TCF is an effector molecule responsible for inflammation and repair in injured tissues including tumor and liver." 08/01/1992 - "Fibroblast-derived tumor cytotoxic factor (F-TCF), isolated from human embryonic lung fibroblasts, is cytotoxic against various human and mouse tumor cells. "
4.	Liver Diseases (Liver Disease) 08/01/1991 - "This ELISA system has the advantage of using a sensitive and reproducible set of monoclonal antibodies, and is a useful method for monitoring F-TCF levels in patients with liver diseases." 08/01/1991 - "F-TCF antigen levels in 21 healthy volunteers was found to be 0.56 +/- 0.43 ng/ml. In contrast, mean F-TCF levels in patients with liver diseases were all higher than those of healthy subjects. " 08/01/1991 - "ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases."
5.	Leukemia 05/01/1991 - "Moreover, F-TCF induced the differentiation of premyelocyte leukemia, HL-60 cells into morphologically granulocyte-like cells. "

Related Drugs and Biologics

1.	fibroblast-derived tumor cytotoxic factor
2.	Cytostatic Agents
3.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
4.	Antigens
5.	Monoclonal Antibodies