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2- amino- 4- hydroxy- 7- (dihydroxypropyl)- 5,6,7,8- tetrahydrobiopterin
a cofactor and potential inhibitor of aromatic amino acid hydroxylases; RN given refers to the 7S-isomer
Also Known As:
2-amino-4-hydroxy-7-(dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin, (7R)-isomer; 7-BH4
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Pteridines: 147
Pterins: 160
Biopterins: 249
2-amino-4-hydroxy-7-(dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin: 3
Enzymes and Coenzymes: 1
Coenzymes: 558
Biopterins: 249
2-amino-4-hydroxy-7-(dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin: 3
Related Diseases
1.
Vitiligo
03/11/1994 - "
Thus, 6-BH4 seems to control melanin biosynthesis in the human epidermis, whereas 7-BH4 may initiate depigmentation in patients with vitiligo.
"
05/25/1994 - "
In vitiligo, the time-dependent production of 7-BH4 is caused by decreased 4a-hydroxytetrahydrobiopterin dehydratase activity; the essential enzyme for recycling and maintaining normal levels of 6-BH-4.
"
05/25/1994 - "
In the epidermis and in cultured melanocytes, 7-BH4 is a potent competitive inhibitor of phenylalanine hydroxylase (Ki = 10(-6) M) and its accumulation in the epidermis of patients with vitiligo blocks the supply of L-tyrosine from L-phenylalanine.
"
2.
Pheochromocytoma
11/01/1992 - "
With both rat brain tryptophan hydroxylase and rat pheochromocytoma tyrosine hydroxylase, the Km value for 7-BH4 is about one order of magnitude greater than the Km for BH4.
"
Related Drugs and Biologics
1.
Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
2.
Tyrosine (L-Tyrosine)
3.
Tryptophan Hydroxylase
4.
Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
5.
Phenylalanine (L-Phenylalanine)
6.
Melanins (Melanin)
7.
Enzymes
8.
pterin-4a-carbinolamine dehydratase