2- amino- 4- hydroxy- 7- (dihydroxypropyl)- 5,6,7,8- tetrahydrobiopterin

a cofactor and potential inhibitor of aromatic amino acid hydroxylases; RN given refers to the 7S-isomer

Also Known As:

2-amino-4-hydroxy-7-(dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin, (7R)-isomer; 7-BH4

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Vitiligo 03/11/1994 - "Thus, 6-BH4 seems to control melanin biosynthesis in the human epidermis, whereas 7-BH4 may initiate depigmentation in patients with vitiligo." 05/25/1994 - "In vitiligo, the time-dependent production of 7-BH4 is caused by decreased 4a-hydroxytetrahydrobiopterin dehydratase activity; the essential enzyme for recycling and maintaining normal levels of 6-BH-4. " 05/25/1994 - "In the epidermis and in cultured melanocytes, 7-BH4 is a potent competitive inhibitor of phenylalanine hydroxylase (Ki = 10(-6) M) and its accumulation in the epidermis of patients with vitiligo blocks the supply of L-tyrosine from L-phenylalanine. "
2.	Pheochromocytoma 11/01/1992 - "With both rat brain tryptophan hydroxylase and rat pheochromocytoma tyrosine hydroxylase, the Km value for 7-BH4 is about one order of magnitude greater than the Km for BH4. "

1.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
2.	Tyrosine (L-Tyrosine)
3.	Tryptophan Hydroxylase
4.	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
5.	Phenylalanine (L-Phenylalanine)
6.	Melanins (Melanin)
7.	Enzymes
8.	pterin-4a-carbinolamine dehydratase