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polyvinylpolypyrrolidone (PVPP)

an insoluble high molecular weight, cross-linked form of PVP (Sigma Catalog 1991 p841)

Also Known As:

PVPP; poly(1-(2-oxo-1-pyrrolidinyl)ethylene)

Networked: 9 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Andrade, Paula B: 1 article (11/2020)
2.	Neves, Dina: 1 article (11/2020)
3.	Rocha, Lídia: 1 article (11/2020)
4.	Valentão, Patrícia: 1 article (11/2020)
5.	Videira, Romeu A: 1 article (11/2020)
6.	Aquilina, Gabriele: 1 article (08/2020)
7.	Boon, Polly: 1 article (08/2020)
8.	Castle, Laurence: 1 article (08/2020)
9.	Crebelli, Riccardo: 1 article (08/2020)
10.	Di Domenico, Alessandro: 1 article (08/2020)

Related Diseases

1.	Aflatoxin Poisoning 01/01/1998 - "This study was conducted in order to evaluate the efficiacy of a polyvinylpolypyrrolidone for protection against aflatoxicosis in broiler chicks. " 01/01/1998 - "The preventive effect of polyvinylpolypyrrolidone on aflatoxicosis in broilers." 07/01/1998 - "Effects of polyvinylpolypyrrolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis."
2.	Necrosis 01/01/1998 - "Grossly, the bursa of Fabricius was atrophied and sections revealed necrosis and depletion of lymphocytes from follicles in 12 broilers of the AF group and two of the AF plus PVPP group. " 07/01/2004 - "Antioxidants, polyvinylpolypyrrolidone (PVPP) and 1,4-dithio-DL-threitol (DTT), were found to improve callus formation, shoot differentiation and growth, and shoot rooting by inhibiting tissue necrosis during the initiation of cultures and subculture of shoots. "
3.	Body Weight (Weight, Body) 08/01/2020 - "The Panel followed the conceptual framework under Commission Regulation (EU) No 257/2010 and considered that: the exposure assessment was based on the reported use and use levels (one food category out of the two food categories in which PVP and PVPP are authorised); the 95th percentile of exposure to PVP and PVPP of maximally 23.7 and 25 mg/kg body weight (bw) per day in children, respectively, was overestimated, because it was assumed that 100% of the food supplements consumed contained PVP or PVPP at the maximum reported use levels; the extension of use of PVP (E 1201) to foods for special medical purposes (FC 13.2) would result in an exposure of PVP of 4.3 mg/kg bw per day for children; the absorption of PVP and PVPP is very low; sufficient toxicity data were available for PVP; there is no concern with respect to the genotoxicity of PVP and PVPP; no carcinogenic effects were reported in carcinogenicity studies in rats at a dose of 2,500 mg PVP/kg bw per day, the highest dose tested; there is no need for chronic toxicity/carcinogenicity data for PVPP for the safety assessment of PVPP given the chemical similarity between PVP and PVPP, and the lack of adverse effects in the available repeated dose toxicity studies. "
4.	Weight Gain 11/01/2012 - "During the investigation period, the weight gain of sorbitol or citric acid increased faster than that of polyvinylpolypyrrolidone or sodium carboxymethyl cellulose at 25°/90% RH, accordingly, the moisture sorption of the tablets containing citric acid or sorbitol (T-3 or T-6) were more than that of the tablets containing sodium carboxymethyl cellulose or polyvinylpolypyrrolidone (T-4 or T-5). "
5.	Fibrosis (Cirrhosis) 07/01/2008 - "Changes in PVPP correlated to changes in WHVP due to changes in PVF only in cirrhosis (r = 0.75, P < 0.001), whereas changes in HAF correlated in both cirrhosis (r = 0.92, P < 0.001) and control (r = 0.77, P < 0.001). " 07/01/2008 - "Absolute changes in HAF correlated to absolute changes in PVPP (cirrhosis: r = 0.64, P < 0.001; control: r = 0.67, P < 0.001) and WHVP (cirrhosis: r = 0.71, P < 0.001; control: r = 0.82, P < 0.001). "

Related Drugs and Biologics

1.	polyvinylpolypyrrolidone (PVPP)
2.	Antioxidants
3.	Polyphenols
4.	Citric Acid (Citrate)
5.	Neuroprotective Agents
6.	Zeolites
7.	Tablets
8.	Sorbitol (Yal)
9.	Sodium
10.	Diatomaceous Earth (Kieselguhr)