PD 136450

gastrin receptor antagonist; dipeptoid which resembles the carboxy-terminal moiety of gastrin

Also Known As:

4-((2- ((3-(1H-indol-3-yl)-2-methyl-1-oxo-2-(((tricyclo(3.3.1.1(3,7))dec-2-yloxy)carbonyl)amino)propyl)amino)-1-phenylethyl)amino)-4-oxo-2-butenoic acid; CAM 1189; CAM-1189; CAM1189; PD-136450; PD136450

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adem, A: 1 article (03/2011)
2.	Bastaki, S M A: 1 article (03/2011)
3.	Chandranath, S I: 1 article (03/2011)
4.	D'Souza, A: 1 article (03/2011)
5.	Singh, J: 1 article (03/2011)

Related Diseases

1.	Stomach Ulcer (Gastric Ulcer) 03/01/2011 - "The results show that both PG and nitric oxide pathways can influence the inhibitory effect of PD-136450 against CRS-induced gastric ulcer. " 03/01/2011 - "PD-136450, an effective anti-secretory agent against gastrin- but not dimaprit-induced stimulation, evoked a dose-dependent inhibition of CRS-induced gastric ulcers. " 03/01/2011 - "The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS." 03/01/2011 - "The results showed that ranitidine was more potent than lansoprazole and PD-136450 in inhibiting CRS-induced gastric ulcers and its effect was shown to be influenced by PG as well as nitric oxide synthase. " 03/01/2011 - "This study compares the antiulcer activities of lansoprazole (a proton pump inhibitor), PD-136450 (CCK(2)/gastrin receptor antagonist) and ranitidine (histamine H(2) receptor antagonist) on CRS-induced gastric ulcers in rats. "
2.	Mental Disorders (Mental Disorder) 06/01/1994 - "The new CCK-B/gastrin receptor antagonist PD 136450 is of potential value in treating neurologic and psychiatric disorders. "

Related Drugs and Biologics

1.	Lansoprazole (Prevacid)
2.	Ranitidine (Zantac)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Cholecystokinin B Receptor
5.	Proton Pump Inhibitors
6.	Histamine (Histamine Dihydrochloride)
7.	Nitric Oxide Synthase (NO Synthase)
8.	Dimaprit
9.	Gastrins