GEA 857

structure given in first source

Also Known As:

2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate; GEA-857; GEA857; valine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester; L-Valine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - GEA 857: 3
  - Essential Amino Acids: 1152
    - Valine: 1999
      - GEA 857: 3

Related Diseases

1.	Tremor (Tremors) 08/01/1992 - "The potentiation of oxotremorine tremor by GEA 857 could be fully blocked by atropine (1 mg/kg intraperitoneally). " 08/01/1992 - "GEA 857 itself did not produce tremor in the absence of the muscarinic agonists or the acetylcholinesterase inhibitors. " 08/01/1992 - "GEA 857, similarly to alaproclate (Ogren et al. 1985a & b), produced a dose-dependent, statistically significant (in the 5-20 mg/kg dose range) enhancement of the tremor response induced by all four cholinergic stimulants. " 08/01/1992 - "GEA 857 [2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate], a structural analogue of the 5-HT uptake blocker alaproclate, was tested for its ability to modify tremor and salivation induced by muscarinic agonists (oxotremorine, arecoline) and acetylcholinesterase inhibitors (physostigmine, THA) in the male rat. "
2.	Seizures (Absence Seizure) 02/01/1997 - "Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP. "
3.	Neuroblastoma 08/01/1992 - "GEA 857 did not affect the carbachol stimulated uptake of 45Ca, but depressed the carbachol activated outflow of 86Rb from neuroblastoma cells. " 08/01/1992 - "The conclusion drawn from these results is that GEA 857 reduces potassium conductances in the membrane in N1E-115 neuroblastoma cells and, thereby, prolongs muscarinic agonist-induced responses." 08/01/1992 - "GEA 857 [2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate], a structural analogue of the serotonin (5-HT) uptake inhibitor alaprocalate but without effects on the 5-HT uptake, was shown to potentiate muscarinic cholinergic responses in N1E-115 neuroblastoma cells. " 08/01/1992 - "GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells."

Related Drugs and Biologics

1.	Muscarinic Agonists
2.	Cholinergic Agents (Cholinergics)
3.	Serotonin (5 Hydroxytryptamine)
4.	alaproclate
5.	N-Methylaspartate (NMDA)
6.	Potassium Channels (Potassium Channel)
7.	Potassium
8.	Physostigmine
9.	Oxotremorine
10.	Harmaline