aglafoline

a platelet activating factor antagonist; structure given in first source; isolated from Aglaia elliptifolia

Also Known As:

1H-Cyclopenta(b)benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1alpha,2alpha,3beta,3abeta,8bbeta)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - aglafoline: 3

Experts

1.	Begum, Tajuddin Nargis: 1 article (01/2020)
2.	Rosita, Arokiaraj Sherlin: 1 article (01/2020)
3.	Carcache-Blanco, Esperanza J: 1 article (01/2007)
4.	Chai, Hee-Byung: 1 article (01/2007)
5.	Douglas Kinghorn, A: 1 article (01/2007)
6.	Farnsworth, Norman R: 1 article (01/2007)
7.	Pawlus, Alison D: 1 article (01/2007)
8.	Salim, Angela A: 1 article (01/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "We show data to support that a compound named aglafoline (methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H cyclopenta [b] [1] from the NPACT (Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database) database have optimal binding features with the TNIK receptor for further consideration in this context." 01/01/2007 - "All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances."
2.	Shock 07/21/1992 - "However, aglafoline (10 mg/kg) both prophylactically and therapeutically antagonized PAF (2.5 micrograms/kg)-induced hypotensive shock in rats. "

Related Drugs and Biologics

1.	Sterols
2.	methyl rocaglate