MCI 826

leukotriene D4 and E4 antagonist; inhibits late asthmatic response; structure in first source

Also Known As:

2,2-diethyl-3'-(2-(2-(4-isopropyl)thiazolyl)ethenyl)succinanilic acid; MCI 826, (E)- isomer; MCI-826; Butanoic acid, 2,2-diethyl-4-((3-(2-(4-(1-methylethyl)-2-thiazolyl)ethenyl)phenyl)amino)-4-oxo-, (E)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - MCI 826: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - MCI 826: 2

Experts

1.	Kawai, T: 1 article (04/2002)
2.	Kohno, S: 1 article (04/2002)
3.	Miura, M: 1 article (04/2002)
4.	Nabe, T: 1 article (04/2002)
5.	Yamashita, K: 1 article (04/2002)

Related Diseases

1.	Vasculitis (Vasculitides) 09/01/1992 - "MCI-826 was found to clearly inhibit LTC4- and LTD4-induced vasculitis, as well as liver and kidney injury. " 09/01/1992 - "In order to confirm the anti-leukotriene activity of MCI-826, the effect of MCI-826 on leukotriene C4(LTC4)- and leukotriene D4(LTD4)-induced vasculitis, liver and kidney injury was studied. "
2.	Nephritis 09/01/1992 - "Moreover, MCI-826 inhibited nephritis, caused by injecting antiglomerular basement membrane antibody into C57BL/6 mice. "
3.	Eosinophilia 04/01/2002 - "We examined the effect of CysLT antagonists (pranlukast and MCI-826) on antigen inhalation-induced eosinophilia in peripheral blood and lung, and on IL-5 activity in serum during late increase of airway resistance (late asthmatic response, LAR) in sensitized guinea-pigs. "

Related Drugs and Biologics

1.	Interleukin-5 (Interleukin 5)
2.	Leukotrienes
3.	Antigens
4.	antiglomerular basement membrane antibody
5.	pranlukast