polyoxyethylene-superoxide dismutase

05/01/1993 - "Although SOD-POE did not affect the decrease of ATP during ischemia, it improved significantly the recovery of ATP: 28%. "
09/01/1991 - "This study was designed to clarify the mechanism of ischemia-reperfusion-induced rat liver injury and to evaluate the effect of long-acting superoxide dismutase (SOD-POE). "
05/01/1993 - "SOD-POE did not affect xanthine oxidase activity during ischemia and reperfusion. "
05/01/1993 - "SOD-POE did not affect LPO levels during ischemia but prevented the increase of LPO significantly after reperfusion (0.98 +/- 0.25 nmol/mg protein). "
09/01/1991 - "SOD-POE did not affect the decrease in ATP levels or the increase in purine nucleotide levels during ischemia. "

05/01/1993 - "This study was designed to clarify the mechanism of ischemia-reperfusion injury to skeletal muscle using long-acting polyoxyethylene-modified superoxide dismutase (SOD-POE) in rats. "
05/01/1993 - "These results suggest that lipid peroxidation by superoxide radicals produced by xanthine oxidase is a contributory factor to ischemia-reperfusion injury to skeletal muscle, and the clinical application of SOD-POE might be expected."

10/01/1990 - "Effect of polyoxyethylene-modified superoxide dismutase on recovery of myocardial dysfunction after coronary stenosis in dogs."
10/01/1990 - "The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. "

05/01/1989 - "In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64.3 to 83.3%), ventricular tachycardia (VT) (66.7 to 84.6%), premature ventricular contraction (PVC) and premature atrial contraction (PAC) occurred immediately after reperfusion and lasted for 1 to 3 min. In both groups treated with SOD-POE (10 U/ml) or native human SOD (10 U/ml), the incidence of Vf and VT was 0% and the number of PVCs significantly decreased. "

05/01/1989 - "In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64.3 to 83.3%), ventricular tachycardia (VT) (66.7 to 84.6%), premature ventricular contraction (PVC) and premature atrial contraction (PAC) occurred immediately after reperfusion and lasted for 1 to 3 min. In both groups treated with SOD-POE (10 U/ml) or native human SOD (10 U/ml), the incidence of Vf and VT was 0% and the number of PVCs significantly decreased. "