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tetradecyl 2'-deoxy-5-fluoro-5'-uridylate
structure given in first source
Also Known As:
TT-62
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleotides: 48
Uracil Nucleotides: 40
Deoxyuracil Nucleotides: 1
Fluorodeoxyuridylate: 99
tetradecyl 2'-deoxy-5-fluoro-5'-uridylate: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Deoxyribonucleotides: 132
Deoxyuracil Nucleotides: 1
Fluorodeoxyuridylate: 99
tetradecyl 2'-deoxy-5-fluoro-5'-uridylate: 1
Pyrimidine Nucleotides: 48
Uracil Nucleotides: 40
Deoxyuracil Nucleotides: 1
Fluorodeoxyuridylate: 99
tetradecyl 2'-deoxy-5-fluoro-5'-uridylate: 1
Related Diseases
1.
Neoplasms (Cancer)
06/01/1992 - "
Thus, oral administration of TT-62 showed marked antitumor activity in both tumor systems.
"
06/01/1992 - "
Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate.
"
06/01/1992 - "
With TT-62 the levels of FdUMP in the tumor reached their peak at 60 min following the administration and gradually decreased thereafter.
"
06/01/1992 - "
Three hours after the administration of TT-62 and for up to 24 h the FdUMP levels in the LS174T tumor were almost the same as after administration of FUdR, i.e.
"
06/01/1992 - "
After oral administration of TT-62 the levels of FdUMP in the tumor were about 10 times those attained with 5-FU, but significantly lower than the levels obtained following i.v. administration of FUdR.
"
2.
Colonic Neoplasms (Colon Cancer)
06/01/1992 - "
The antitumor effect and tumor levels of 5-fluoro-2'-deoxyuridylate (FdUMP) following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate (TT-62) were compared with those attained following intravenous (i.v.) or intraperitoneal (i.p.) administration of 5-fluorouracil (5-FU) or 5-fluoro-2'-deoxyuridine (FUdR) in BDF1 mice bearing murine mammary adenocarcinoma 755 and athymic mice bearing the transplantable human colon adenocarcinoma LS174T.
"
3.
Adenocarcinoma
06/01/1992 - "
Oral administration of TT-62 showed a stronger antitumor effect against adenocarcinoma 755 than FUdR.
"
06/01/1992 - "
The antitumor effect and tumor levels of 5-fluoro-2'-deoxyuridylate (FdUMP) following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate (TT-62) were compared with those attained following intravenous (i.v.) or intraperitoneal (i.p.) administration of 5-fluorouracil (5-FU) or 5-fluoro-2'-deoxyuridine (FUdR) in BDF1 mice bearing murine mammary adenocarcinoma 755 and athymic mice bearing the transplantable human colon adenocarcinoma LS174T.
"
Related Drugs and Biologics
1.
Fluorouracil (Carac)
2.
Fluorodeoxyuridylate
3.
Floxuridine (FUdR)
4.
5-fluoro-2'-deoxyuridine
Related Therapies and Procedures
1.
Oral Administration