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glutaryl-2-(hydroxymethyl)anthraquinone
Also Known As:
2-(hydroxymethyl)anthraquinone-hemiglutarate; G-HMAQ
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
Anthrones: 12
Anthraquinones: 788
glutaryl-2-(hydroxymethyl)anthraquinone: 3
Quinones: 434
Anthraquinones: 788
glutaryl-2-(hydroxymethyl)anthraquinone: 3
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
Anthrones: 12
Anthraquinones: 788
glutaryl-2-(hydroxymethyl)anthraquinone: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1996 - "
Both T-98 and [D-Lys6]LH-RH significantly inhibited the growth of MXT cancers, but G-HMAQ had only a minor non-significant effect.
"
01/01/1993 - "
Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition.
"
04/01/1992 - "
Cytotoxic luteinizing hormone-releasing hormone (LH-RH) analogs, AJ-004 (agonist [D-Lys6]LH-RH linked to methotrexate (MTX)), T-98 ([D-Lys6]LH-RH coupled to glutaryl-2-(hydroxymethyl)anthraquinone) (G-HMAQ) and T-121/B (antagonist containing two residues of G-HMAQ) were tested in female BDF1 mice bearing MXT ((3.2)/Ovex) estrogen-independent mammary tumors.
"
2.
Breast Neoplasms (Breast Cancer)
01/01/1993 - "
Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition.
"
Related Drugs and Biologics
1.
Gonadotropin-Releasing Hormone (GnRH)
2.
lysine(6)- glutaryl- 2- (hydroxymethyl)anthraquinone LHRH (T 98)
3.
Methotrexate (Mexate)
4.
Estrogens (Estrogen)
5.
Anthraquinones
6.
ovex