esculentoside A

potent inhibitor of PAF synthesis in rat peritoneal macrophages

Also Known As:

Olean-12-ene-28,29-dioic acid, 3-((4-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxy-, 29-methyl ester, (2beta,3beta,4alpha,20beta)-

Networked: 24 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Oleanolic Acid: 547
        esculentoside A: 24
      - Sapogenins: 26
        Oleanolic Acid: 547
        esculentoside A: 24
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - esculentoside A: 24

Experts

1.	Okunieff, Paul: 2 articles (03/2015 - 07/2006)
2.	Xiao, Zhenyu: 2 articles (01/2010 - 07/2006)
3.	Du, Xiubo: 1 article (01/2022)
4.	Feng, Jiale: 1 article (01/2022)
5.	He, Zhijun: 1 article (01/2022)
6.	Li, Nan: 1 article (01/2022)
7.	Li, Xiaoqian: 1 article (01/2022)
8.	Liu, Qiong: 1 article (01/2022)
9.	Ni, Jiazuan: 1 article (01/2022)
10.	Tu, Sixin: 1 article (01/2022)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 10/30/2017 - "Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats." 09/01/2017 - "Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ."
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/2023 - "The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease." 04/01/2022 - "Esculentoside A alleviates cognitive deficits and amyloid pathology through peroxisome proliferator-activated receptor γ-dependent mechanism in an Alzheimer's disease model."
3.	Atopic Dermatitis (Atopic Eczema) 11/01/2023 - "Esculentoside A ameliorates DNCB-induced atopic dermatitis by suppressing the ROS-NLRP3 axis via activating the Nrf2 pathway."
4.	Inflammation (Inflammations) 11/01/2023 - "Esculentoside A (EsA) inhibits inflammation and oxidative stress in various diseases. " 01/01/2015 - "Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway." 06/01/2004 - "To investigate the influence of esculentoside A (EsA) on immunological function and its mechanism of anti-inflammation. " 07/01/2022 - "Esculentoside A could attenuate apoptosis and inflammation in TNBS-induced ulcerative colitis via inhibiting the nuclear translocation of NF-κB." 03/09/2020 - "Esculentoside A protects against osteoarthritis by ameliorating inflammation and repressing osteoclastogenesis."
5.	Necrosis 01/01/1996 - "Inhibitory effect of esculentoside A on tumour necrosis factor alpha production by human monocytes." 01/01/1992 - "Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages."

Related Drugs and Biologics

1.	Dinitrochlorobenzene (DNCB)
2.	Saponins
3.	Peroxisome Proliferator-Activated Receptors (PPAR)
4.	Dexamethasone (Maxidex)
5.	Caspases
6.	Cytokines
7.	Triterpenes
8.	Lipopolysaccharides
9.	Indicators and Reagents (Reagents)
10.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Punctures
2.	Ligation