IGN 2098

may be useful for treatment of gastric and duodenal lesions in humans

Also Known As:

5,6-dimethyl-2-(4-(3-(1-piperidinomethyl)phenoxy)cis-butenylamino)-4-(1H)-pyrimidone dihydrochloride; IGN-2098; 4(1H)-Pyrimidinone, 5,6-dimethyl-2-((4-(3-(1-piperidinylmethyl)phenoxy)-2-butenyl)amino)-, dihydrochloride, (Z)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - IGN 2098: 3
  - Piperidines: 17
    - IGN 2098: 3

Related Diseases

1.	Ulcer 03/01/1995 - "Based on these results, it is concluded that IGN-2098 may be a useful drug for the clinical treatment of ulcer and that the healing acceleration by IGN-2098 without prominence of the ulcer edge may induce no relapse of the ulcer after healing." 03/01/1995 - "All drugs accelerated the healing of the ulcer, and the effect of IGN-2098 was the most remarkable. " 03/01/1995 - "[Therapeutic effect of IGN-2098, a new antiulcer drug (H2-antagonist), in the ulcer diminishing period against acetic acid-induced gastric ulcer in rats]."
2.	Stomach Ulcer (Gastric Ulcer) 03/01/1995 - "[Therapeutic effect of IGN-2098, a new antiulcer drug (H2-antagonist), in the ulcer diminishing period against acetic acid-induced gastric ulcer in rats]." 03/01/1995 - "The effects of IGN-2098 on the healing process of acetic acid-induced gastric ulcer was investigated in comparison with the other histamine H2-receptor antagonists, famotidine and roxatidine acetate HCl, in rats. "
3.	Peptic Ulcer (Peptic Ulcers) 08/01/1993 - "These results show that IGN-2098 is a potent and long acting antisecretory agent and is a useful antisecretory drug for the treatment of peptic ulcer disease."
4.	Fistula 03/01/1992 - "Stimulated gastric secretion in fistula rats in response to histamine, carbachol or pentagastrin was also significantly inhibited with IGN-2098 given s.c. "
5.	Duodenal Ulcer (Curling's Ulcer) 03/01/1992 - "As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	roxatidine acetate (roxatidine)
3.	Therapeutic Uses
4.	Acetic Acid (Vinegar)
5.	Famotidine (Pepcid)
6.	Pentagastrin (Peptavlon)
7.	Epirizole
8.	Carbachol (Carbastat)
9.	Aspirin (Acetylsalicylic Acid)