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azatoxin
structure given in first source; a topoisomerase II inhibitor
Also Known As:
1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole; NSC 640737; NSC 640737-M; NSC-640737M
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
azatoxin: 2
Related Diseases
1.
Neoplasms (Cancer)
06/22/1993 - "
The present study was undertaken in order to investigate the molecular pharmacology and the cytotoxic activity of azatoxin in human tumor cells.
"
05/11/1995 - "
Azatoxin was rationally designed as a DNA topoisomerase II (top2) inhibitor [Leteurtre et al., Cancer Res 52: 4478-4483, 1992] and was also found to inhibit tubulin polymerization.
"
06/22/1993 - "
Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor (Leteurtre et al., Cancer Res 52: 4478-4483, 1992).
"
2.
Colonic Neoplasms (Colon Cancer)
06/22/1993 - "
We found that azatoxin inhibited tubulin polymerization in vitro and was a mitotic inhibitor at 1 microM and above in the human colon cancer cell line KM20L2.
"
Related Drugs and Biologics
1.
Tubulin
2.
azatoxin
3.
Topoisomerase II Inhibitors
4.
A-Form DNA (A-DNA)
5.
Type II DNA Topoisomerases (Topoisomerase II)