azatoxin

structure given in first source; a topoisomerase II inhibitor

Also Known As:

1H,6H-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole; NSC 640737; NSC 640737-M; NSC-640737M

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 06/22/1993 - "The present study was undertaken in order to investigate the molecular pharmacology and the cytotoxic activity of azatoxin in human tumor cells. " 05/11/1995 - "Azatoxin was rationally designed as a DNA topoisomerase II (top2) inhibitor [Leteurtre et al., Cancer Res 52: 4478-4483, 1992] and was also found to inhibit tubulin polymerization. " 06/22/1993 - "Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor (Leteurtre et al., Cancer Res 52: 4478-4483, 1992). "
2.	Colonic Neoplasms (Colon Cancer) 06/22/1993 - "We found that azatoxin inhibited tubulin polymerization in vitro and was a mitotic inhibitor at 1 microM and above in the human colon cancer cell line KM20L2. "

1.	Tubulin
2.	azatoxin
3.	Topoisomerase II Inhibitors
4.	A-Form DNA (A-DNA)
5.	Type II DNA Topoisomerases (Topoisomerase II)