1,2- dihydroxy- 5,6- dimethyl- 3,4- epoxy- 1,2,3,4- tetrahydrochrysene
structure given in first source; RN given refers to ((1alpha,2beta,2abeta,3abeta)-(+-))-isomer; RN for cpd without isomeric designation not available 9/92
Also Known As:
5,6-diMeC-1,2-diol-3,4-epoxide; 5,6-diMeCDE; 5,6-dimethylchrysene-1,2-diol-3,4-epoxide
Networked: 1
relevant articles (0 outcomes,
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Bio-Agent Context: Research Results
Related Diseases
1. | Neoplasms (Cancer)
01/01/1998
- " 5,6-diMeCDE, at initiating doses of 33, 100 or 400 nmol per mouse, induced 1.2, 2.2 and 6.2 skin tumors per mouse, respectively. " 01/01/1998
- " No mutations were found in codons 12 and 13 in the tumors induced by 5,6-diMeCDE. " 01/01/1998
- " Tumors induced by 5,6-diMeCDE had a large number of CAA-->CTA mutations in codon 61 of the Ha-ras gene: 50, 55 and 75% of the tumors analysed had this mutation at the 33, 100 and 400 nmol doses. "
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