Brachyury protein (Brachyury)

required for mesoderm formation; involved in the transcriptional regulation of genes required for mesoderm formation and differentiation; amino acid sequence known; Brachyury (Greek for short tail) or T (tail) gene product; RefSeq NM_009309 (mouse), NM_003181 (human); homologous brachyury protein found in other mammals

Also Known As:

Networked: 131 relevant articles (2 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Palena, Claudia: 15 articles (10/2015 - 04/2007)
2.	Schlom, Jeffrey: 11 articles (11/2015 - 04/2007)
3.	Fernando, Romaine I: 11 articles (03/2015 - 04/2007)
4.	Hamilton, Duane H: 10 articles (03/2015 - 02/2010)
5.	Huang, Bruce: 7 articles (05/2014 - 05/2011)
6.	Flanagan, Adrienne M: 7 articles (11/2012 - 01/2007)
7.	Tirabosco, Roberto: 7 articles (11/2012 - 01/2007)
8.	Tsang, Kwong-Yok: 4 articles (12/2014 - 07/2012)
9.	Litzinger, Mary T: 4 articles (05/2014 - 05/2011)
10.	Litzinger, Mary: 4 articles (07/2012 - 04/2007)

Related Diseases

1.	Chordoma 09/01/2015 - "In conclusion, the results of the present study demonstrated that the expression of Brachyury offers a sensitive marker, but not a risk factor, for skull base chordomas, and radical surgery is recommended." 11/01/2014 - "Several studies demonstrated brachyury expression (T; 6q27) as a possible candidate gene in the oncogenesis of chordomas (e.g. " 11/01/2012 - "Recent genomic studies have identified duplication of the gene brachyury as a major susceptibility mutation in familial chordomas. " 10/01/2011 - "The authors propose that Brachyury is an attractive therapeutic target in chordoma and that JHC7 will serve as a clinically relevant model for the study of this disease." 08/01/2010 - "Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases."
2.	Meningioma (Meningiomas) 07/01/2012 - "Thus, brachyury cytoplasmic staining was demonstrated to be highly specific for HBL (specificity, 100%) and represented a sensible (sensitivity, 91%) method, with high positive (100%) and negative (89%) predictive values and high diagnostic accuracy (95%) in the differential diagnosis between HBL and CCRCC metastatic to the CNS or meningioma. " 07/01/2012 - "No nuclear or cytoplasmic staining for brachyury was observed in any of the primary renal or metastatic CCRCCs, nor in either of the meningioma types. " 07/01/2012 - "Archival tissues from 22 HBLs, 16 primary CCRCCs, 8 CCRCCs metastatic to the CNS, and 4 angiomatous and 4 clear cell meningiomas were retrieved from our surgical pathology files and submitted to the immunohistochemical procedures against brachyury. " 11/01/2014 - "Our study suggests that a positive staining for brachyury, galectin-3, and Ki-67 would be helpful for differential diagnosis, discriminating intradural retroclival chordoma from ecchordosis physaliphora and chordoid meningioma. " 05/01/2009 - "Our findings demonstrate that in conjunction with clinical and radiographic findings, immunohistochemical evaluation with a panel of D2-40, EMA, brachyury, and GFAP is most useful in distinguishing chordoid meningioma from chordoid glioma, skeletal myxoid chondrosarcoma, extraskeletal myxoid chondrosarcoma, chordoma, low-grade chondrosarcoma, and enchondroma. "
3.	Albuminuria 01/01/2014 - "Black and tan, brachyury (BTBR) mice deficient for the leptin receptor (ob/ob) develop many of the pathological features of human DN and, remarkably, treatment with exogenous leptin ameliorates hyperglycaemia, albuminuria and glomerulosclerosis. "
4.	Neoplasms (Cancer) 10/01/2015 - "In this study, we immunohistochemically evaluated 5229 different tumors for nuclear brachyury expression using a new rabbit monoclonal antibody and automated immunostaining (Leica Bond Max). " 09/15/2014 - "In this study, we aimed to assess the impact of Brachyury expression in prostate tumorigenesis using a large series of human prostate samples comprising benign tissue, prostate intraepithelial neoplasia (PIN) lesions, localized tumor, and metastatic tissues. " 10/01/2013 - "Previous studies have demonstrated that brachyury is a driver of the epithelial-mesenchymal transition (EMT), a process associated with cancer progression. " 01/01/2013 - "In this study, we further characterize this model and demonstrate that it continues to resemble the original patient tumor histologically and immunohistochemically, maintains nuclear expression of brachyury, and is highly concordant with the original patient tumor by whole genome genotyping. " 09/01/2015 - "Kaplan‑Meier analysis revealed that the degree of surgery, rather than the expression of brachyury, was associated with tumor recurrence (P=0.001). "
5.	Neoplasm Metastasis (Metastasis) 01/01/2014 - "The study findings suggest that elevated Brachyury facilitates HCC metastasis by promoting EMT via PTEN/Akt/Snail-dependent pathway. " 01/01/2014 - "The present study aimed to evaluate the critical role of Brachyury in HCC metastasis. " 01/01/2014 - "Brachyury plays a pivotal role in HCC metastasis and may serve as a novel prognostic biomarker and therapeutic target." 01/01/2014 - "Overexpression of Brachyury promoted epithelial-mesenchymal transition (EMT) and metastasis of HCC cells in vitro and in vivo. " 01/01/2014 - "Clinicopathological analysis revealed a close correlation of Brachyury expression with distant metastasis and poor prognosis of HCC. "

Related Drugs and Biologics

1.	Galectin 3 (LGALS3)
2.	Leptin Receptors
3.	Leptin
4.	Transcription Factors (Transcription Factor)
5.	Mucin-1 (CA 15-3 Antigen)
6.	CD15 Antigens
7.	Vaccines
8.	Steroidogenic Factor 1
9.	Osteopontin
10.	Osteocalcin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Transplantation (Transplant Recipients)
5.	Radiotherapy