cizolirtine

structure given in first source; analgesic with no ulcerogenic effects

Also Known As:

1-methyl-5-((2,N,N-dimethylaminoethoxy)(phenyl)methyl)-1H-pyrazole citrate; E 4018; E-4018; Ethanamine, N,N-dimethyl-2-((1-methyl-1H-pyrazol-5-yl)phenylmethoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate

Networked: 18 relevant articles (8 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - cizolirtine: 18

Experts

1.	Guzmán, Antonio: 3 articles (07/2022 - 02/2021)
2.	Marín, Ana-Paz: 3 articles (07/2022 - 02/2021)
3.	Tortajada, Araceli: 3 articles (07/2022 - 02/2021)
4.	Vila, Cristina: 3 articles (07/2022 - 02/2021)
5.	Abadías, Montserrat: 3 articles (01/2010 - 07/2004)
6.	Bourgoin, Sylvie: 3 articles (02/2007 - 07/2003)
7.	Farré, Antonio: 3 articles (02/2007 - 07/2003)
8.	Hamon, Michel: 3 articles (02/2007 - 07/2003)
9.	Kayser, Valérie: 3 articles (02/2007 - 07/2003)
10.	Encina, Gregorio: 2 articles (07/2022 - 06/2021)

Related Diseases

1.	Urinary Incontinence 07/01/2009 - "Cizolirtine showed a clear improvement regarding the percentage of patients free from urinary incontinence episodes at the end of the study, being 68.75% in C400, 45% in C200, and 30% in placebo (p=0.04; C400 vs placebo). " 02/01/2021 - "The analysis of the genotoxic potential of cizolirtine, a compound being developed as a drug for analgesia and for urinary incontinence, was carried out using a battery of in vitro and in vivo assays as recommended in the guidelines for medicinal products. " 01/01/2010 - "Cizolirtine citrate is a promising agent in the treatment of OAB with urinary incontinence." 07/01/2009 - "Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 07/01/2009 - "Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study."
2.	Overactive Urinary Bladder (Overactive Bladder) 07/01/2009 - "The therapeutic potential of cizolirtine citrate 400mg bid in overactive bladder has been evidenced." 07/01/2009 - "Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 07/01/2009 - "Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 07/01/2009 - "Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 01/01/2010 - "Cizolirtine citrate is safe and effective for treating urinary incontinence secondary to overactive bladder: a phase 2 proof-of-concept study."
3.	Hyperalgesia 01/01/2001 - "Similarly, allodynia improved with cizolirtine (p = 0.03) but not with placebo (p = 0.9) in this subgroup. " 07/01/2004 - "Under acute conditions, cizolirtine (30 and 80 mg/kgi.p.) significantly increased paw withdrawal and vocalization thresholds in the paw pressure test in diabetic rats displaying mechanical hyperalgesia. " 07/01/2003 - "of cizolirtine reversed both mechanical and thermal allodynia. " 01/01/2001 - "In a subgroup of five patients with primary allodynia, a 53% reduction in VAS score from baseline at rest (p = 0.007) and 55% on movement (p = 0.0002) at day 21 was observed with cizolirtine, as compared to 8% at rest (p = 0.5215) and 13% on movement (p = 0.4187) with placebo. " 01/01/2001 - "Results showed that the differences in VAS and allodynia scores between cizolirtine and placebo treatments were not significant in the overall analysis (p > or = 0.05); cizolirtine was well tolerated. "
4.	Peripheral Nerve Injuries 01/01/2001 - "Cizolirtine may be effective in primary allodynia after peripheral nerve injury, and a further trial in a larger number of such subjects is warranted."
5.	Diabetic Neuropathies (Diabetic Neuropathy) 07/01/2004 - "Cizolirtine was compared to paroxetine, an antidepressant drug with proven efficacy to relieve painful diabetic neuropathy. " 02/01/2007 - "Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy."

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Streptozocin (Streptozotocin)
3.	Non-Narcotic Analgesics (Analgesics, Non Narcotic)
4.	Paroxetine (Paxil)
5.	Antidepressive Agents (Antidepressants)
6.	Analgesics (Analgesic Drugs)
7.	Sodium
8.	Dipyrone (Metamizole)
9.	Calcitonin Gene-Related Peptide
10.	Substance P

Related Therapies and Procedures

1.	Drug-Eluting Stents
2.	Stents
3.	Anesthesia
4.	Analgesia