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8-epi-prostaglandin F2alpha

Subscribe to New Research on 8-epi-prostaglandin F2alpha

a potent preglomerular vasoconstrictor acting principally through thromboxane A2 receptor activation

Also Known As:

15-F(2t)-IsoP; 15-F(2t)-isoprostane; 8-F(2t)-isoprostane; 8-epi-PGF2 alpha; 8-epi-PGF2alpha; 8-epiprostaglandin F2alpha; 8-iso-PGF(2alpha); 8-iso-PGF2alpha; 8-isoprostaglandin F2alpha; 8-isoprostane; isoprostaglandin F2alpha type-III; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8beta,9alpha,11alpha,13E,15S)-

Networked: 428 relevant articles (13 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Antczak, Adam: 12 articles (08/2015 - 08/2002)
2.	Barnes, Peter J: 12 articles (01/2011 - 08/2002)
3.	Basu, Samar: 11 articles (01/2007 - 10/2002)
4.	Montuschi, Paolo: 9 articles (01/2010 - 08/2002)
5.	Górski, Paweł: 8 articles (12/2014 - 01/2010)
6.	Ciabattoni, Giovanni: 8 articles (01/2010 - 07/2003)
7.	Piotrowski, Wojciech J: 7 articles (07/2012 - 08/2007)
8.	Marczak, Jerzy: 7 articles (07/2012 - 08/2007)
9.	Ciebiada, Maciej: 6 articles (08/2015 - 12/2010)
10.	Bhattacharya, Syamal K: 6 articles (09/2014 - 09/2008)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/2009 - "Exhaled breath condensate (EBC) levels of 8-isoprostane (IsoP), which is a known marker of oxidative stress, might therefore be helpful for monitoring asthma noninvasively. " 06/01/2013 - "The objective of this study was to evaluate EBC 8-isoprostane concentrations following allergen-induced bronchoprovocation in asthma. " 09/01/2009 - "Our study shows that oxidative stress is increased significantly in asthmatic subjects and the degree of oxidative stress in EB subjects is milder than that in asthma, as reflected by 8-isoprostane concentrations in the BAL fluid. " 09/01/2007 - "To investigate changes in oxidant stress during and following acute asthma exacerbations, this study measured 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (F(2)-IsoP-M), the major urinary metabolite of 15-F(2t)-IsoP, in eight asthmatic adults, during and following an asthma hospitalization. " 02/01/2004 - "Our study shows that EBC cys-LTs and 8-isoprostane concentrations are higher in asthmatic children than in healthy control children, with scattered values in patients with unstable asthma. "
2.	Inflammation 05/01/2003 - "Administration of gammaT led consistently to a significant reduction of inflammation-mediated increase in 8-isoprostane, a biomarker of lipid peroxidation. " 03/01/2005 - "In this study, we investigated the potential role of 8-iso-PGF2alpha in inflammation, focusing on its effects on adhesion of monocytes to microvascular endothelial cells, an early event in the inflammatory response. " 02/01/2013 - "Over four weeks, exhaled breath condensate was collected twice a week from 18 asthmatics and 18 nonasthmatics (ages 14-19 years) attending two New York City schools and analyzed for pH and 8-isoprostane as indicators of airway inflammation and oxidative stress, respectively. " 11/01/2010 - "The strict correlation between cys-LTs and 8-isoprostane underlines the relationship between allergic inflammation and oxidative stress. " 06/01/2008 - "Exhaled breath 8-isoprostane concentrations increased after exposure to CAPs (16.9+/-8.5 vs. 4.9+/-1.2 pg/mL, p<0.05), but markers of systemic inflammation were largely unchanged. "
3.	Infection 03/01/2006 - "Analysis of the concentrations of 8-isoprostane and MPO in exhaled breath condensate allows assessment of oxidative stress in the airways of patients with severe lung infections." 11/01/2006 - "Elevation of 8-isoprostane in patients with hepatitis C virus infection undergoing hemodialysis." 05/01/2008 - "In addition, the combination of urinary 15-F(2t)-IsoP above the mean and chronic hepatitis B virus (HBV) infection resulted in an OR of 19.01 (95% CI = 6.67-54.17) compared with those with low urinary 15-F(2t)-IsoP and without HBV infection. " 01/01/2005 - "Successful eradication of H pylori infection led to a significant reduction in both 8-iso-PGF(2alpha) and 11-dehydro-TXB2. " 01/01/2010 - "viverrini infection also increased two to three times in the plasma inflammatory indicators, 8-isoprostane, malondialdehyde, and nitrate/nitrite. "
4.	Type 2 Diabetes Mellitus (MODY) 01/19/1999 - "Improved metabolic control was associated with a significant (P=0.0001) reduction in 8-iso-PGF2alpha and TXM excretion by 32% and 41%, respectively, in 21 NIDDM patients. " 05/01/2001 - "The excretion of 8-iso-PGF(2alpha), was increased in type 2 diabetes mellitus compared to non-diabetic control subjects. " 05/01/2001 - "We studied the urinary excretion of 8-iso-PGF(2alpha) and related it to PON M/L55 genotypes in patients with type 2 diabetes mellitus (n = 55) and non-diabetic control subjects (n = 55). " 08/18/2000 - "Enhanced urinary excretion of 8-iso-PGF(2alpha) has been described in association with both type 1 and type 2 diabetes mellitus, and correlates with impaired glycemic control. " 07/17/1995 - "We found that the average concentration of esterified 8-epi-PGF2 alpha among NIDDM subjects (0.93 +/- 0.07 nM, n = 39) was higher (P < 0.0001, Mann-Whitney test) than in healthy individuals (0.28 +/- 0.04 nM, n = 15). "
5.	Gastroesophageal Reflux (GERD) 01/01/2007 - "Two months of PPI therapy improved the pH (from 7.2 +/- 0.1 to 7.3 +/- 0.1) and the 8-isoprostane concentration (from 32.7 +/- 3.4 to 19.2 +/- 3.4) in the asthma patients with GERD, along with improvement of GERD symptoms. " 09/01/2009 - "There are still problems to be overcome before EBC can be used clinically, but pH and 8-isoprostane may be promising objective markers of airway inflammation due to GERD. " 09/01/2009 - "A decrease of pH and an increase of the 8-isoprostane concentration in EBC have been observed in patients with mild to moderate asthma accompanied by GERD. " 11/01/2007 - "Breath collected by cooling can be applied to pH, 8-isoprostane and cytokine analysis in patients with GERD-related asthma, and the pH and 8-isoprostane levels have been shown to reflect the effects of PPI therapy in these patients. " 01/01/2007 - "Measurement of the pH and 8-isoprostane level of exhaled breath condensate may be useful to evaluate the influence of GERD on asthma, as well as to determine the timing of intermittent PPI therapy."

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