Optisol

contains minimal essential tissue culture medium with 2.5% chondroitin sulfate, dextran-40, several vitamins, gentamicin & ATP precursor agents added; used for corneal storage

Networked: 20 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hoover, Caroline: 3 articles (11/2018 - 07/2014)
2.	Jeng, Bennie H: 3 articles (11/2018 - 07/2014)
3.	Duncan, Katherine: 2 articles (11/2018 - 04/2016)
4.	Parker, Jeff: 2 articles (11/2018 - 04/2016)
5.	Bachmann, Bjoern O: 2 articles (09/2013 - 07/2012)
6.	Cursiefen, Claus: 2 articles (09/2013 - 07/2012)
7.	Kruse, Friedrich E: 2 articles (09/2013 - 07/2012)
8.	Chamani, Tahereh: 1 article (12/2021)
9.	Javadi, Mohammad Ali: 1 article (12/2021)
10.	Rezaei Kanavi, Mozhgan: 1 article (12/2021)

Related Diseases

1.	Mycoses (Diseases, Fungus) 01/01/2021 - "The incidence of fungal infection after corneal transplant has increased significantly in recent years, especially Candida spp. This study aimed to evaluate the efficacy and safety of the addition of cycloheximide in Optisol-GS media in decreasing the growth of Candida spp. strains. " 04/01/2016 - "Given the increasing incidence of postkeratoplasty fungal infection, however, the addition of amphotericin B to Optisol-GS deserves further investigation." 07/01/2014 - "The addition of amphotericin B to Optisol-GS may significantly improve activity against contamination with Candida species, the primary cause of fungal infection after corneal transplantation. " 11/01/2018 - "The incidence of postkeratoplasty fungal infection is increasing in the United States, and our most commonly used corneal storage medium, Optisol-GS, contains antibiotics but no antifungal agents. "
2.	Infections 10/01/2013 - "Optisol-GS was contaminated with microorganisms related to corneal infections, and different times after contamination was analyzed using a closed-chamber study model. " 10/01/2013 - "To evaluate the existence of in vitro long-term antimicrobial activity of Optisol-GS against microorganisms related to corneal infection using a closed-chamber study model. " 01/01/1998 - "Newer storage medium, such as Optisol GS, might have a role in preventing keratoplasty-related infection." 11/01/2017 - "Reduced room temperature incubation and the addition of antifungal agents decreased growth of Candida species in optisol-GS and should be further explored to reduce the risk of infection."
3.	Endophthalmitis (Ophthalmia) 11/01/2017 - "Candida albicans, Candida glabrata, and Candida parapsilosis endophthalmitis isolates were each inoculated into optisol-GS and subjected to 2 different room temperature incubation regimens reflective of current corneal tissue handling protocols. " 04/01/2005 - "After the introduction of Optisol-GS, the odds of bacterial relative to fungal endophthalmitis decreased by 77% (95% confidence interval, 44% - 91%). "
4.	Keratoconus 10/01/2008 - "Lyophilized corneas can be used successfully for DALK to treat keratoconus with results similar to Optisol corneas." 10/01/2008 - "Deep anterior lamellar transplant using lyophilized and Optisol corneas in patients with keratoconus." 03/27/1999 - "Clinical efficacy was evaluated in a total of 83 patients: 10 patients with keratoconus grafted randomly with either CM- or Optisol-stored cornea of the same donor, and 73 patients with various conditions grafted with CM-stored corneas. "
5.	Eye Infections 01/01/2008 - "To determine the incidence of positive corneoscleral rim cultures preserved in Optisol GS medium, to identify pathogens involved and possible recipient eye infection. "

Related Drugs and Biologics

1.	Cycloheximide (Cicloheximide)
2.	Chondroitin Sulfates (Chondroitin Sulfate)
3.	Antifungal Agents
4.	Amphotericin B (Amphotericin)
5.	Polypropylenes (Polypropylene)
6.	Dextrans (Dextran)
7.	Buffers
8.	Anti-Bacterial Agents (Antibiotics)
9.	Aluminum Oxide (Sapphire)
10.	sodium phosphate (trisodium phosphate)

Related Therapies and Procedures

1.	Corneal Transplantation (Keratoplasty)
2.	Sutures (Suture)
3.	Intraocular Lenses (Intraocular Lens)
4.	Lasers (Laser)