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transthyretin-methionine(111)

has substitution of methionine for leucine at position 111; associated with hereditary amyloidosis and cardiomyopathy

Also Known As:

TTR-Met111

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Albumins: 31532
    - Serum Albumin: 9893
      - Prealbumin: 4971
        transthyretin-methionine(111): 1
  - Blood Proteins: 12459
    - Serum Albumin: 9893
      - Prealbumin: 4971
        transthyretin-methionine(111): 1

Related Diseases

1.

Cardiomyopathies (Cardiomyopathy)

07/01/1992 - "That the occurrence in serum of TTR-Met111 precedes the onset of clinical amyloid cardiomyopathy by several decades makes the variant TTR a marker for the disease. "
07/01/1992 - "All sera from family members with amyloid cardiomyopathy contained the variant transthyretin TTR-Met111 as did sera from half of their offspring. "
07/01/1992 - "The occurrence in serum of the mutant transthyretin TTR-Met111 is linked to the occurrence of amyloid cardiomyopathy in patients and their offspring, while unafflicted branches of the family are negative for the variant protein. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Prealbumin (Transthyretin)
3.	Amyloid (Amyloid Fibrils)