phillyrin

Also Known As:

4-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-2-methoxyphenyl, (1S-(1alpha,3aalpha,4beta,6aalpha))-beta-D-glucopyranoside; forsythin; beta-D-Glucopyranoside, 4-((1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-2-methoxyphenyl

Networked: 40 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - phillyrin: 40

Experts

1.	Jiang, Qian: 2 articles (01/2021 - 02/2020)
2.	Long, Xiaobing: 2 articles (01/2021 - 02/2020)
3.	Zhang, Huaqiu: 2 articles (01/2021 - 02/2020)
4.	Cao, Dayan: 1 article (07/2022)
5.	Chen, Xin: 1 article (07/2022)
6.	Li, Xiaohui: 1 article (07/2022)
7.	Liu, Qiao: 1 article (07/2022)
8.	Luo, Qingman: 1 article (07/2022)
9.	Tang, Kecheng: 1 article (07/2022)
10.	Yang, Shengqian: 1 article (07/2022)

Related Diseases

1.	Infections 07/01/2016 - "Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus. " 07/01/2016 - "In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. " 04/19/2021 - "In this review, we summarized our studies on the biological effects of forsythia leaves containing phillyrin and other polyphenolic compounds, particularly against obesity, atopic dermatitis, and influenza A virus infection, and its potential as a phytoestrogen." 11/13/2023 - "We reported that phillyrin (15 mg/kg) treatment after viral challenge significantly improved the weight loss, ameliorated pulmonary inflammation and inhibited the accumulation of multiple cytokines and chemokines in bronchoalveolar lavage fluid on 7 days post infection (dpi). "
2.	Diabetic Nephropathies (Diabetic Nephropathy) 07/15/2022 - "Phillyrin, a well-known natural compound from the dried fruits of Forsythia suspensa (Thunb.) Vahl., has shown anti-inflammatory, antioxidant and anti-virus activities as well as renal protective effects on diabetic nephropathy. " 12/01/2021 - "Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice."
3.	Pneumonia (Pneumonitis) 11/13/2023 - "In this work, the effect and mechanism of phillyrin on H1N1 influenza (PR8)-induced pneumonia were investigated. " 10/01/2013 - "Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice." 11/13/2023 - " study reveals that phillyrin ameliorates IAV-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation partly." 11/13/2023 - "Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation." 11/13/2023 - "Moreover, phillyrin inhibited the mRNA and protein expression levels of Caspase1, ASC and NLRP3 in the lungs of mice with H1N1-induced pneumonia.This"
4.	Weight Loss (Weight Reduction) 11/13/2023 - "We reported that phillyrin (15 mg/kg) treatment after viral challenge significantly improved the weight loss, ameliorated pulmonary inflammation and inhibited the accumulation of multiple cytokines and chemokines in bronchoalveolar lavage fluid on 7 days post infection (dpi). "
5.	Obesity 02/01/2005 - "To study on the anti-obesity effect of phillyrin in nutritive obesity mice. " 01/01/2022 - "Firstly, a mouse model of diet-induced obesity is used to assess the pharmacological applications of Phillyrin on obesity in vivo. " 07/01/2014 - "Phillyrin, an active ingredient found in many medicinal plants and certain functional foods, elicits anti-obesity and anti-inflammatory properties in vivo. " 01/15/2013 - "Phillyrin, an active constituent found in many medicinal plants and certain functional foods, has anti-obesity activity in vivo. " 02/01/2005 - "Phillyrin has anti-obesity effect in nutritive obesity mice."

Related Drugs and Biologics

1.	Inflammasomes
2.	Cytokines
3.	Antioxidants
4.	Chemokines
5.	Streptozocin (Streptozotocin)
6.	Antiviral Agents (Antivirals)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Lipopolysaccharides
9.	Phytoestrogens (Phytoestrogen)
10.	Peroxidase (Myeloperoxidase)

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)