fraxinellone

12/01/2023 - "We then established in vitro intestinal fibrosis cell models in SW480 and HT-29 cells, and demonstrated that treatment with fraxinellone (3, 10, 30 μM) significantly relieved TGF-β-induced fibrosis responses by inhibiting the TGF-β/Smad2/3 signaling pathway. "
12/01/2023 - "Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium."
01/01/2021 - "In conclusion, these findings demonstrated that fraxinellone might be a new drug candidate and CUGBP1 could be a promising target for the treatment of kidney fibrosis."
01/01/2021 - "However, the effect of fraxinellone on kidney fibrosis is largely unknown. "
12/01/2021 - "Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy."

03/13/2018 - "Fraxinellone attenuated the clinical and histologic features of inflammatory arthritis in CIA mice. "
03/13/2018 - "The data suggests that fraxinellone could be a novel treatment for inflammatory arthritis, including rheumatoid arthritis."
03/13/2018 - "This study aimed to evaluate the therapeutic effect of fraxinellone on inflammatory arthritis and identify the underlying mechanisms. "

12/01/2021 - "Fraxinellone ameliorates intracerebral hemorrhage-induced secondary brain injury by regulating Krüppel-like transcription factor 2 expression in rats."

12/01/2021 - "Fraxinellone ameliorates intracerebral hemorrhage-induced secondary brain injury by regulating Krüppel-like transcription factor 2 expression in rats."

12/01/2021 - "Furthermore, fraxinellone treatment effectively alleviated brain edema, decreased the levels of TNF-α and IL-1β, and improved neuronal cell degeneration induced by ICH. "