tetrapeptide carbamate

09/08/2009 - "Analysis of human intestinal tumors at various stages showed a systematic down-regulation of PC5/6 expression. "
06/11/1997 - "PC5 expression was detected in 2/30 tumor tissues. "
01/01/1985 - "In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. "
01/01/2015 - "In a mouse model for HCC expression of Furin was not altered in the tumors, while those of PC7, PC5/6, and PACE4 significantly decreased, at least at some time points. "
03/23/2012 - "Furin increased in tumors, whereas PC5/6, PACE4 and PC7 expression was reduced with increasing cancer grades. "

04/01/2005 - "In the present study, we investigated the localization of furin and PC5 in different stages of human atherosclerosis. "
11/01/2005 - "Based on these recent in vitro and in vivo data, furin and PC5 are potential contributors to the initiation, progression, and complications of atherosclerosis and restenosis. "
11/01/2005 - "Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels."
05/31/2005 - "Furin and PC5 are expressed in human peripheral blood mononuclear cells and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque, supporting the hypothesis that they are potential targets in atherosclerosis."

09/08/2009 - "Since PC5/6 is highly expressed in the small intestine, the present study examined its in vivo role in intestinal tumorigenesis. "
09/08/2009 - "Overall, these data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon."
06/01/2003 - "The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis."

02/01/2001 - "Fluorogenic peptides encompassing the processing sites of envelope glycoproteins of the infectious influenza A Hong Kong virus (HKV), Ebola virus (EBOV) and respiratory syncytial virus (RSV) were tested for cleavage by soluble recombinants of the proprotein convertases furin, PC5 and PC7. "
03/21/2017 - "chinense, ellagic acid (PC5), methyl gallate (PC7) and caffeic acid (PC8) significantly inhibited viral replication in a dose-dependent manner in both plaque inhibition and CPE inhibition assays with EC50 values ranging from 14.7 to 81.1 μg/mL and CC50 values higher than 300 μg/mL. Mode-of-action studies suggested that PC5 and PC7 suppress virus entry into or replication in cells, while PC8 targets influenza viral neuraminidase, even oseltamivir-resistant one. "

01/01/2014 - "The aim of this study is to investigate the emetic effects and mechanisms involving serotonin and dopamine of needleless transcutaneous electroacupuncture (TEA) at Neiguan (PC6) and Jianshi (PC5) on chemotherapy-induced nausea and vomiting in patients with cancers. "