alnespirone

S 20499 is the (+)-enantiomer; S 20500 is the (-)-enantiomer

Also Known As:

(+)-(S)-N-(4-((5-methoxy-3-chromanyl)propylamino)butyl)-1,1-cyclopentanediacetimide; (+)-4-N-(5-methoxychromane-3-yl) N-propylaminobutyl-8-azapiro 4,5-decane-7,9-dione hydrochloride; (-)-4-N-(5-methoxychromane-3-yl) N-propylaminobutyl-8-azapiro 4,5-decane-7,9-dione hydrochloride; 4-(N-(5-methoxychroman-3-yl)-N-propylamino)butyl-8-azaspiro(4,5)decane-7,9-dione; 4-N-(5-methoxychromane-3-yl) N-propylaminobutyl-8-azapiro 4,5-decane-7,9-dione hydrochloride; 8-(4-(N-(5-methoxychroman-3-yl)-N-propyl)aminobutyl)-8-azaspiro(4,5)decane-7,9-dione; S 20244; S 20499; S 20500; S-20244; S-20499; S-20500; S20244

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bertaglia, A: 1 article (04/2000)
2.	Cervo, L: 1 article (04/2000)
3.	Munoz, C: 1 article (04/2000)
4.	Samanin, R: 1 article (04/2000)

Related Diseases

1.	Hypothermia 04/01/1994 - "Acutely, S-20499 resembled CDP in inducing hypothermia. " 07/01/1994 - "The inability of (+) S-20499 either to induce the 5-HT syndrome or forepaw treading or to attenuate the forepaw treading induced by other agonists could be due to several factors, one of which is that different subtypes of the 5-HT1A receptor mediate hypothermia and the 5-HT syndrome."
2.	Mood Disorders (Mood Disorder) 01/01/1999 - "Given the therapeutic potential of selective 5-HT1A agonists in the treatment of affective disorders, we have examined the changes in 5-HT1A receptors induced by 2-week minipump administration of alnespirone (0.3 and 3 mg/kg/day) and 8-OH-DPAT (0.1 and 0.3 mg/kg/day). "
3.	Weight Loss (Weight Reduction) 04/01/1994 - "In contrast to S-20499 withdrawal, CDP withdrawal induced weight loss and aphagia. "
4.	Body Weight (Weight, Body) 04/01/1994 - "When S-20499 was withdrawn there was no evidence of any effect on body weight or food intake. " 04/01/1994 - "Acutely, S-20499 decreased body weight and food intake and complete tolerance developed to these effects. " 04/01/1994 - "CDP differed from S-20499 in some of its acute effects, stimulating body weight and food intake. "
5.	Anxiety Disorders (Anxiety Disorder) 04/01/2000 - "Like buspirone, alnespirone may have useful effects in the treatment of anxiety disorders."

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
3.	Serotonin (5 Hydroxytryptamine)
4.	Cytidine Diphosphate (CDP)
5.	Buspirone (Buspar)