hippocampal cholinergic neurostimulating peptide

amino acid sequence given in first source; involved in development of specific cholinergic neurons in central nervous system

Also Known As:

HCNP; L-Leucine, N-(1-(N-(N-(N-(N2-(N-(N-(N-(N-(N-acetyl-L-alanyl)-L-alanyl)-L-alpha-aspartyl)-L-isoleucyl)-L-seryl)-L-glutaminyl)-L-tryptophyl)-L-alanyl)glycyl)-L-prolyl)-

Networked: 16 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - hippocampal cholinergic neurostimulating peptide: 16
- Peptides: 82426
  - Neuropeptides: 6772
    - hippocampal cholinergic neurostimulating peptide: 16

Experts

1.	Matsukawa, Noriyuki: 5 articles (06/2014 - 02/2002)
2.	Ojika, Kosei: 4 articles (01/2012 - 02/2002)
3.	Borlongan, Cesario V: 3 articles (01/2012 - 07/2007)
4.	Akatsu, Hiroyasu: 2 articles (02/2009 - 02/2002)
5.	Hattori, Manabu: 2 articles (02/2009 - 07/2007)
6.	Maki, Mina: 2 articles (02/2009 - 02/2002)
7.	Nakazawa, Hideka: 2 articles (02/2009 - 07/2007)
8.	Yuasa, Hiroyuki: 2 articles (07/2007 - 02/2002)
9.	Katada, E: 2 articles (03/2001 - 01/2000)
10.	Matsukawa, N: 2 articles (03/2001 - 01/2000)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 06/01/2014 - "HCNP and HCNP-pp might be candidates for the key molecules as a therapeutic target in Alzheimer's disease." 11/01/1998 - "By contrast, the early-onset Alzheimer's disease patients could be divided on the basis of their HCNP level into two groups, one with high levels (markedly above the mean +/- 2SD range), and the other with levels similar to those of the other patients. " 02/01/1995 - "The number of HCNP-positive Hirano bodies was greater in patients with Alzheimer's disease than in normal, age-matched individuals. " 11/01/1998 - "The analysis of the CSF samples obtained postmortem revealed that Group I Alzheimer-type dementia (ATD) patients with clinico-pathologically established diagnoses had a strikingly higher level of HCNP than patients with either Group II ATD or cerebral vascular disease. " 02/06/2009 - "Our previous study demonstrated that expression of HCNPpp mRNA was decreased in the hippocampi of autopsied brains of Alzheimer's disease (AD) patients, indicating the association of HCNP with the pathogenesis of AD. "
2.	Stroke (Strokes) 01/01/2012 - "This study therefore aimed to elucidate the involvement of HCNP-pp in specific neural lineages after stroke using a hypoxic-ischemic (HI) rat model of brain ischemia. "
3.	Nervous System Diseases (Neurological Disorders) 03/29/2001 - "In this study, we examined the HCNP-antigen distribution and the age-related changes in the number of positive cells in the hippocampus (obtained at autopsy from 74 subjects with no known neurological disorders). "
4.	Learning Disabilities (Learning Disability) 01/01/2000 - "Furthermore, several lines of evidence obtained from studies of humans and animal models suggest that certain types of memory and learning disorders are associated with abnormal accumulation and expression of HCNP analogue peptide and/or its precursor protein mRNA in the hippocampus."
5.	Brain Ischemia (Cerebral Ischemia) 01/01/2012 - "This study therefore aimed to elucidate the involvement of HCNP-pp in specific neural lineages after stroke using a hypoxic-ischemic (HI) rat model of brain ischemia. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	Antigens
5.	hippocampal cholinergic neurostimulating peptide
6.	Matrix Metalloproteinase 2 (Gelatinase A)
7.	Cholinergic Agents (Cholinergics)
8.	tau Proteins (tau Protein)
9.	Amyloid beta-Peptides
10.	N-Methylaspartate (NMDA)