squalestatin 1

structure given in first source; inhibits both mammalian and fungal squalene synthetase; from fungus Phoma sp (Coelomycetes)

Also Known As:

7-deoxy zaragozic acid; squalestatin; squalestatin s1; zaragozic acid A; L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-c-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-((2E,4S,6S)-4,6-dimethyl-2-octenoate), (7S)-

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Omori, Masahide: 1 article (09/2021)
2.	Shidoji, Yoshihiro: 1 article (09/2021)
3.	Tabata, Yuki: 1 article (09/2021)
4.	Aizaki, Hideki: 1 article (02/2015)
5.	Fukasawa, Masayoshi: 1 article (02/2015)
6.	Hanada, Kentaro: 1 article (02/2015)
7.	Nishijima, Masahiro: 1 article (02/2015)
8.	Saito, Kyoko: 1 article (02/2015)
9.	Shirasago, Yoshitaka: 1 article (02/2015)
10.	Suzuki, Tetsuro: 1 article (02/2015)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 09/17/2021 - "In addition, we found that upregulation of endogenous GGA levels by zaragozic acid A (ZAA) induced cell death in human hepatoma-derived cells. " 02/01/2015 - "By using the HCV JFH-1 strain and human hepatoma Huh-7.5.1-derived cells, we found that the SQS inhibitors YM-53601 and zaragozic acid A decreased viral RNA, protein, and progeny production in HCV-infected cells without affecting cell viability. "
2.	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/09/2004 - "The protective effect of squalestatin, which was reversed by the addition of water-soluble cholesterol, correlated with a reduction in prostaglandin E(2) production that is associated with neuronal injury in prion disease. "
3.	Virus Diseases (Viral Diseases) 03/01/2007 - "In hepatocytes pre-treated with squalestatin or 25-hydroxycholesterol before infection, viral RNA accumulation increased or decreased in parallel with LDLR mRNA expression and LDL entry. "
4.	Neoplasms (Cancer) 06/29/2007 - "Similar effects are observed when cancer cells are treated with the chemical SQS inhibitor zaragozic acid A. "
5.	Infections 03/01/2007 - "Infection was performed in the absence or presence of LDL, HDL, recombinant soluble LDLR peptides encompassing full-length (r-shLDLR4-292) or truncated (r-shLDLR4-166) LDL-binding domain, monoclonal antibodies against r-shLDLR4-292, squalestatin or 25-hydroxycholesterol. "

Related Drugs and Biologics

1.	Cholesterol
2.	Cholestanetriol 26-Monooxygenase (Cholestanetriol 26 Monooxygenase)
3.	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)
4.	Viral RNA
5.	Messenger RNA (mRNA)
6.	RNA (Ribonucleic Acid)
7.	Proteins (Proteins, Gene)
8.	Prostaglandins
9.	Peptides (Polypeptides)
10.	Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)