Staphylococcus aureus glutamic acid-specific endopeptidase (SPase)

amino acid sequence given in first source; cleaves peptide bonds on the C-terminal side of glutamic acid; not identical to V8 protease

Also Known As:

SPase; glutamic acid-specific endopeptidase, Staphylococcus aureus; prepro-SPase

Networked: 19 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Staphylococcus aureus glutamic acid-specific endopeptidase: 19

Experts

1.	Chérifi, Fatah: 1 article (07/2018)
2.	Laraba-Djebari, Fatima: 1 article (07/2018)
3.	Saoud, Samah: 1 article (07/2018)
4.	Fujiwara, Sakuhei: 1 article (06/2014)
5.	Hatano, Yutaka: 1 article (06/2014)
6.	Sakai, Takashi: 1 article (06/2014)
7.	Zhang, Wei: 1 article (06/2014)
8.	Balducci, F: 1 article (12/2013)
9.	Bonneterre, V: 1 article (12/2013)
10.	Laloua, F: 1 article (12/2013)

Related Diseases

1.	Pain (Aches) 06/01/2023 - "This study used a thorough development process to create the Scale for Pain Self-Efficacy (SPaSE) in both German and English languages. " 06/01/2023 - "The valid and reliable SPaSE can be used in clinical practice to monitor pain treatment progress, advances the field of pain self-efficacy research in Germany, and opens the door to comparative research in German and English samples. " 06/01/2023 - "Sum scores of the SPaSE were negatively correlated with pain-related disability, pain intensity, passive pain coping strategies, and emotional distress, in line with previous research. " 06/01/2023 - "Development and Validation of the Scale for Pain Self-Efficacy (SPaSE) in German and English Languages for Children and Adolescents."
2.	Infections 02/01/2013 - "Knockdown of the expression of CH-SPase in WSSV-infected Chinese shrimp reduced the copy number of WSSV and delayed cumulative mortalities, suggesting that CH-SPase is important for WSSV infection. " 11/01/2009 - "Furthermore, we demonstrated that SPase I not only is an attractive target for development of novel antibacterials against free-living bacteria, but also is a feasible target for biofilm-associated infections." 09/01/2012 - "SPase activity is also of fundamental importance to the pathogenesis of infection for many bacteria, including Pseudomonas aeruginosa, which utilizes a variety of secreted virulence factors, such as proteases and toxins. "
3.	Retinoblastoma (Glioblastoma, Retinal) 04/10/1997 - "Transcription factor, SP1, and retinoblastoma susceptible gene product, RB, are substrates of SPase while other nuclear factors such as c-Jun and c-Fos are not. " 04/01/2005 - "SPase is a cysteine protease isolated from an African green monkey kidney cell line, CV-1, and has selective cleavage activity toward transcription factor SP-1 and retinoblastoma susceptibility gene product RB. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 04/01/2002 - "With SPASE, they were 16.4% higher in the acute hepatitis group, 33.3% higher in the chronic hepatitis group, and the positive rates were 73.6% and 61.2% respectively in sera of hepatic cirrhosis patients, which were remarkably higher than those in chronic hepatitis and acute hepatitis group (P<0.001). " 07/10/2001 - "TIMP-1 and TIMP-2 in the serum of 106 patients with liver cirrhosis were detected by solid-phase absorption to sensitized erythrocytes (SPASE). " 04/01/2002 - "SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, and TIMP-1 and TIMP-2 can be considered as a useful diagnostic index of hepatic fibrosis, especially TIMP-1." 04/01/2002 - "The monoclonal antibodies (McAbs) of TIMP-1 and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) was used to detect TIMP-1 and TIMP-2 in the sera of patients with hepatic cirrhosis. "
5.	Type A Niemann-Pick Disease 05/01/1978 - "By employing this technique, it was shown that cells from patients with Niemann-Pick disease type A have less than 10% of the normal SPase activity, whereas the heterozygote carriers of this disease have about 50% of the normal activity." 05/01/1978 - "A method is developed for the detection of homozygotes and heterozygote carriers of Niemann-Pick disease type A by employing a high performance liquid chromatography (HPLC) technique for the measurement of sphingomyelin (SP) as well as for the assay of the enzyme sphingomyelinase (SPase) in skin fibroblasts and amniotic fluid cell cultures. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Serine Proteases (Serine Protease)
3.	Tissue Inhibitor of Metalloproteinase-2
4.	Tissue Inhibitor of Metalloproteinase-1
5.	type I signal peptidase (signal peptidase)
6.	Cysteine Proteases (Cysteine Protease)
7.	Lipopeptides
8.	Chemokine CCL17
9.	Virulence Factors (Pathogenicity Factors)
10.	Sp1 Transcription Factor