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rilmakalim
potassium channel opener; rimalkalim may be a typo
Also Known As:
3-hydroxy-2,3-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-phenylsulfonylchroman hemihydrate; HOE 234; HOE-234; rimalkalim; 2-Pyrrolidinone, 1-(3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)-2H-1-benzopyran-4-yl)-, (3S-trans)-
Networked:
4
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromans: 3
rilmakalim: 4
Pyrrolidines: 115
rilmakalim: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromans: 3
rilmakalim: 4
Experts
1.
Kocic, I
: 1 article (03/2009)
2.
Sztormowska, K
: 1 article (03/2009)
Related Diseases
1.
Asthma (Bronchial Asthma)
01/07/1992 - "
Administration of 30 micrograms/kg i.v. HOE 234 during continuous bronchoconstriction maintained by infusion of histamine decreased RL for more than 20 min whereas the effect of 100 micrograms/kg i.v. lemakalin disappeared within 4 min. These results show that HOE 234 is effective against contractile response induced by asthma mediators in guinea pig airways and compares favourably with lemakalim.
"
06/01/1996 - "
The possible advantages of HOE 234 as an anti-asthma drug might be related to an effect on bronchial hyper-reactivity and mucus secretion, because as a direct bronchodilator it is inferior to salbutamol.
"
2.
Pulmonary Hypertension
03/01/2009 - "
Our results imply that pulmonary hypertension increased sensitivity of sinoatrial cells to isoprenaline and decreased efficacy of rilmakalim to reduce heart rate more significantly in females then in males.
"
3.
Heart Failure
08/01/1995 - "
The functional role of ATP-dependent potassium (KATP) in hypoxic cardiac failure was investigated in isolated guinea pig hearts with glibenclamide and rimalkalim as inhibitor and activator, respectively.
"
Related Drugs and Biologics
1.
Cromakalim (Levcromakalim)
2.
Isoproterenol (Isoprenaline)
3.
Histamine (Histamine Dihydrochloride)
4.
Potassium
5.
Glyburide (Glibenclamide)
6.
Bronchodilator Agents (Bronchodilators)
7.
Albuterol (Salbutamol)
8.
Adenosine Triphosphate (ATP)