galantide (M 15)

consists of 20-amino acid residues, 12 AA from the N-terminal of galanin and the C-terminal part of Substance P; blocks the galanin-mediated inhibition of glucose-induced insulin secretion; amino acid sequence given in first source

Also Known As:

M 15; M15; M-15; galanin (1-12)-Pro-substance P (5-11); L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-

Networked: 112 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lamont, S J: 5 articles (12/2018 - 01/2008)
2.	Kim, D K: 4 articles (04/2016 - 01/2008)
3.	Lillehoj, H S: 4 articles (04/2016 - 01/2008)
4.	Carati, Colin J: 4 articles (08/2010 - 02/2010)
5.	Saccone, Gino T P: 4 articles (08/2010 - 02/2010)
6.	Schloithe, Ann C: 4 articles (08/2010 - 02/2010)
7.	Toouli, James: 4 articles (08/2010 - 02/2010)
8.	Hong, Y H: 3 articles (04/2016 - 01/2008)
9.	Barreto, Savio G: 3 articles (08/2010 - 02/2010)
10.	Zhang, Yan: 2 articles (01/2021 - 01/2007)

Related Diseases

1.	Pancreatitis 06/01/2010 - "We have previously shown that galantide ameliorates mild acute pancreatitis (AP), and the salivary tripeptide analogue, feG, ameliorates severe AP in mice. " 02/01/2010 - "Galantide and L703,606 individually, and in combination, significantly reduced the acute pancreatitis-induced necrosis score. " 08/01/2010 - "We have previously shown that galantide, a non-specific galanin receptor antagonist, ameliorates acute pancreatitis (AP) induced in mice. " 06/01/2010 - "The efficacy of combining feG and galantide in mild caerulein-induced acute pancreatitis in mice." 02/01/2010 - "We compared the efficacy of the combination of the galanin antagonist galantide and the neurokinin-1 receptor antagonist L703,606 with that of either alone in the treatment of acute pancreatitis. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 12/01/1992 - "The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. " 02/01/1992 - "A parallel group-randomized comparison of the therapeutic efficacy of chloroquine (CQ), amodiaquine (AM), quinine (QN), sulphadoxine-pyrimethamine (S-P), mefloquine 15 mg kg-1 (M15) and mefloquine 25 mg kg-1 (M25) in acute symptomatic uncomplicated falciparum malaria was carried out in 325 children under the age of five years in Ibadan, southwestern Nigeria, using the 28-day in vivo test. "
3.	Malaria 11/01/2004 - "In Kachin State, northern Myanmar, an area of low seasonal malaria transmission, the efficacy of CQ (25 mg base/kg) and SP (1.25/25 mg/kg), the nationally recommended treatments at the time, were compared with mefloquine alone (M; 15 mg base/kg) and mefloquine combined with artesunate (MA; 15:4 mg/kg). "
4.	Schizophrenia (Dementia Praecox) 04/01/2009 - "We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. " 09/05/2008 - "For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: rs2111902 (MDAAO-4), rs3918346 (MDAAO-5), rs3741775 (MDAAO-6) and rs3918347 (MDAAO-7) in DAO and rs746187 (M7), rs3916966 (M13), rs2391191 (M15) and rs3916972 (M25) in G72. " 12/16/1981 - "Nursing care study - chronic schizophrenia: time lords, royalty and M15." 02/01/1996 - "The double-blind acute phase of this study compared three dosage ranges of olanzapine (5 +/- 2.5 mg/day [Olz-L], 10 +/- 2.5 mg/day [Olz-M], 15 +/- 2.5 mg/day [Olz-H]) to a dosage range of haloperidol (15 +/- 5 mg/day [Hal]) and to placebo in the treatment of 335 patients who met the DSM-III-R criteria for schizophrenia. "
5.	Neoplasms (Cancer) 05/01/2013 - "Metabolites M14 and M15 were tested for cancer cell growth inhibition and induction of apoptosis and both showed substantial activity, with M14 displaying greater potency than 6S. " 01/01/2013 - "Semistructured telephone interviews were conducted with young people (N = 15, age: M = 15.9 years) who had a parent diagnosed with cancer within the last 5 years. " 07/01/2007 - "thuringiensis strain M15 exhibits specific cytocidal activities against some human cancer cells. " 12/01/1998 - "65 deaths have occurred with a follow-up of 2 to 120 months (m = 15), including 2 postoperative deaths, 39 cancer deaths and 14 intercurrent deaths. " 01/01/1988 - "Approximately 100 unselected cells in each tumor were classified into seven types as follows: undifferentiated (10%-62%, m: 29%), histiocytelike (8%-69%, m: 37%), fibroblastlike (0.9%-26%, m: 11%), myofibroblasts (0%-22%, m: 3%), intermediate between histiocytelike and fibroblastlike cells (1%-41%, m: 15%), multinucleated giant (0%-1%), and xanthomatous cells (0%-1%). "

Related Drugs and Biologics

1.	Mefloquine (Lariam)
2.	Galanin
3.	Galanin Receptors (Galanin Receptor)
4.	Ceruletide
5.	Neurokinin-1 Receptor Antagonists
6.	Quinine (Quinson)
7.	Chloroquine (Aralen)
8.	Amodiaquine (Camoquin)
9.	Artesunate
10.	pyrimethamine drug combination fanasil (Fansidar)

Related Therapies and Procedures

1.	Nursing Care
2.	Intravenous Infusions
3.	Therapeutics
4.	Electrodes (Electrode)
5.	Oral Administration