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U 74389F

a 21-aminosteroid antioxidant (lazaroids); inhibitor of iron-dependent lipid peroxidation; structure in first source

Also Known As:

21-(4-(2,6-di-1-pyrrolidinyl-4- pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione monomethanesulfonate; Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-, monomethanesulfonate; U 74389; U 74389G; U-74389; U-74389F; U-74389G; U74389F; desmethyl tirilazad; trilazad mesylate

Networked: 100 relevant articles (21 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnatrienes
      - U 74389F: 100

Experts

1.	Papalois, Apostolos: 7 articles (07/2015 - 09/2003)
2.	Papalois, Apostolos E: 4 articles (09/2015 - 04/2014)
3.	Agrogiannis, George: 4 articles (03/2015 - 04/2014)
4.	Liapi, Charis: 3 articles (07/2015 - 06/2012)
5.	Bimpis, Alexios: 3 articles (07/2015 - 06/2012)
6.	Patsouris, Efstratios S: 3 articles (03/2015 - 04/2014)
7.	Flessas, Ioannis: 3 articles (03/2015 - 04/2014)
8.	Toutouzas, Konstantinos: 2 articles (09/2015 - 01/2015)
9.	Psaltopoulou, Theodora: 2 articles (03/2015 - 04/2014)
10.	Zagouri, Flora: 2 articles (03/2015 - 04/2014)

Related Diseases

1.	Reperfusion Injury 04/01/1999 - "Early cardiac function following Tx was significantly better and histological damage was less in the Lazaroid-treated group than in the control group, suggesting that Lazaroid U-74389G is effective in preventing ischemia-reperfusion injury after preservation and Tx." 04/01/1999 - "To investigate the role of eicosanoid generation and neutrophilic infiltration in the protective effects of U74389F against ischemia/reperfusion injury in the small intestines of rats. " 11/01/1998 - "Lazaroid U-74389G ameliorates ischemia-reperfusion injury in canine hearts: a histologic study." 11/01/1999 - "Lazaroid U-74389G ameliorates ischemia-reperfusion injury caused by Pringle's procedure during extensive liver resection. " 06/01/1995 - "Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat."
2.	Ischemia 03/01/2015 - "This swine model of pancreatic ischemia and reperfusion, encompassing preconditioning, indicates that U-74389G lazaroid does not seem to exert protective effects from pancreatic damage." 11/01/1994 - "We conclude that whereas SOD was detrimental, the lazaroid analogue U-74389F improved microvascular perfusion following 3 h of no-flow ischemia and 90 min reperfusion." 03/01/2015 - "The present study focuses specifically on the pancreas and aims to examine any effects of U-74389G in a swine model of pancreatic ischemia and reperfusion, encompassing ischemic preconditioning. " 04/01/2014 - "The aim of our study was to evaluate the therapeutic potential of 21-aminosteroid U-74389G in pancreatic injury after ischemia and reperfusion of the organ in a swine model. " 01/01/2014 - "The aim of this experiment was to study the effects of the antioxidant drug "U-74389G" on rat model, particularly in ischemia reperfusion protocol. "
3.	Hyperoxia 02/01/1998 - "Protective effects of the lazaroid U-74389G against hyperoxia in rat type II pneumocytes." 01/01/1993 - "However, U-74389F did not inhibit the hyperoxia-induced accumulation of neutrophils in bronchoalveolar lavage fluid. " 03/16/1998 - "Administration of U-74389G offers some degree of protection against hyperoxia and attenuation of these biomarkers of oxidation, but the precise mechanisms by which this protection is effected will require additional study." 02/01/1998 - "The aims of this study were to investigate the effect of hyperoxia on O2(-.), H2O2 and .NO generation and iNOS mRNA levels in rat type II pneumocytes in vitro and the possible protective effect of the lazaroid U-74389G. " 07/01/1997 - "The aim of the study was to investigate (1) the effects of in vitro hyperoxia on gamma-GT activity of type II cells and (2) the effects of the lazaroid U-74389G and N-acetylcysteine (NAC) on the hyperoxia-induced changes in gamma-GT and antioxidant enzyme activities. "
4.	Brain Ischemia (Cerebral Ischemia) 01/01/1997 - "These results are in agreement with the neuroprotective efficacy of desmethyl tirilazad in cerebral ischemia." 03/01/1996 - "The present study revealed that U-74389G attenuated delayed neuronal death in global cerebral ischemia when it was administered before or soon after the ischemic episode." 03/01/1996 - "Therapeutic time window for the 21-aminosteroid, U-74389G, in global cerebral ischemia." 01/01/1997 - "In our current study the neuroprotective potential of the 21-aminosteroid U-74389G was compared with that of the pyrrolopyrimidine U-101033E in a rat model of reversible focal cerebral ischemia. " 10/01/1998 - "Pretreatment with desmethyl tirilazad or dizocilpine maleate or nimodipine individually significantly suppressed (p < 0.01) the increase in cNOS activity and cGMP levels induced by cerebral ischemia, which may be related to their neuroprotective effect. "
5.	Hypothermia 04/01/1998 - "Protection by the 21-aminosteroid at normothermic conditions, or additional protection when U-74389G was added to mild hypothermia, could not be demonstrated." 04/01/1998 - "Forty male anesthetized New Zealand white rabbits were randomized to four groups (n = 10): (a) normothermia (control); (b) U-74389G (3 mg/kg intravenously [i.v.] before aortic occlusion, 1.5 mg/kg i.v. and 10 mg/kg intraperitoneally after occlusion); (c) mild hypothermia (4 degrees C epidural temperature decrease); and (d) mild hypothermia combined with U-74389G. " 03/01/1996 - "Treatment with moderate hypothermia (32 degrees C for 4 h), a 21-aminosteroid (U-74389G, Upjohn, 10 mg/kg intravenously, repeated 3 h after the first dose), or both, was initiated 10, 25, or 40 min after injury. " 04/01/1998 - "In this study we compared the effects of mild hypothermia and the 21-aminosteroid U-74389G, alone and in combination on neurologic and histopathologic outcome after temporary spinal cord ischemia. " 04/01/1998 - "Effect of mild hypothermia and the 21-aminosteroid U-74389G on neurologic and histopathologic outcome after transient spinal cord ischemia in the rabbit."

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Related Therapies and Procedures

1.	Lasers (Laser)
2.	Surgical Instruments (Clip)
3.	Heart Transplantation (Grafting, Heart)
4.	Intravenous Infusions
5.	Intravenous Injections