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tensins (tensin)

has both actin-binding & phosphotyrosine-binding activity; known component of focal adhesion; may link signal transduction pathways with cytoskeleton; amino acid sequence has been determined; has sequence homology to insertin

Also Known As:

tensin; C-terminal tensin-like protein, human; Cten protein, human; TNS1 protein, human; TNS3 protein, human; TNS4 protein, human; Tns protein, rat; Tns1 protein, mouse; Tns4 protein, mouse; tensin 1 protein, human; tensin 1 protein, mouse; tensin 3 protein, human; tensin 4 protein, human; tensin 4 protein, mouse; tensin protein, rat; tensin3 protein, human

Networked: 1339 relevant articles (21 outcomes, 136 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eng, Charis: 25 articles (10/2015 - 11/2002)
2.	Wu, Hong: 11 articles (07/2012 - 12/2004)
3.	Pandolfi, Pier Paolo: 10 articles (05/2015 - 10/2002)
4.	Simmen, Rosalia C M: 9 articles (09/2014 - 12/2004)
5.	Lo, Su Hao: 8 articles (06/2014 - 08/2002)
6.	Leslie, Nick R: 8 articles (11/2012 - 01/2004)
7.	Ross, Alonzo H: 8 articles (10/2010 - 01/2003)
8.	Schlomm, Thorsten: 7 articles (12/2015 - 08/2012)
9.	Sauter, Guido: 7 articles (11/2015 - 08/2012)
10.	Simon, Ronald: 7 articles (11/2015 - 08/2012)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2004 - "Herein, we replicated these findings in another Sprague-Dawley substrain (Charles River) and examined whether WPH protective effects were associated with altered mammary gland differentiation status and expression of the tumor suppressor phosphatase and tensin homolog deleted in chromosome ten (PTEN). " 03/05/2013 - "Despite this improved survival, the number of axons that regrow beyond the injury site is substantially reduced, even when the tumor suppressor phosphatase and tensin homolog (PTEN) is deleted to enhance intrinsic growth potential. " 02/01/2014 - "Although such 'escape' from senescence is not sufficient to promote thyroid tumorigenesis in adult mice up to 5 months, the onset of Phosphatase and tensin homolog (Pten)-induced tumor formation is accelerated when Spry1 is concomitantly eliminated. " 02/01/2012 - "To assess the efficacy of multiple treatment of phosphatidylinositol-3-kinase (PI3K) inhibitor on autochthonous tumours in phosphatase and tensin homologue (Pten)-deficient genetically engineered mouse cancer models using a longitudinal magnetic resonance imaging (MRI) protocol. " 10/23/2015 - "For cancer immunoediting, this study aimed to investigate the decrease of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor protein, leading to cellular impairment of IFN-γ signaling. "
2.	Glioblastoma (Glioblastoma Multiforme) 10/01/2015 - "The study aimed to explore the specific function and mechanism of miR-144-3p in glioblastoma (GBM) cells with different phosphatase and tensin homolog (PTEN) phenotypes. " 01/03/2006 - "Our previous study suggests that the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene, one of the most frequently mutated genes in glioblastomas, restricts neural stem/progenitor cell proliferation in vivo. " 03/12/2015 - "Here we show that miR-26a, which is often amplified in glioblastoma, promotes invasion in phosphatase and tensin homolog (PTEN)-competent and PTEN-deficient glioblastoma cells by directly downregulating KAP expression. " 01/01/2012 - "Glioblastoma multiforme (GBM) is a highly invasive and aggressive primary brain tumour in which loss of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a negative regulator of PI3K signalling, is a common feature. " 08/01/2008 - "Deletion or mutation of phosphatase and tensin homolog located on chromosome ten (PTEN) occurs in as high as 80% glioblastoma. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "Phosphatase and tensin homolog (PTEN), a well-known tumor suppressor gene and frequently mutated or lost in breast cancer, possesses the negative regulation function over the PI3K/Akt/mTOR pathway. " 11/01/2014 - "The tumour suppressor activity of the phosphatase and tensin homologue on chromosome 10 (PTEN) is subject of intense investigative efforts, although limited information on its regulation in breast cancer is available. " 01/01/2014 - "Phosphatase and tensin homolog (PTEN), a negative regulator of this pathway, is typically lost in ER-negative breast cancer. " 01/01/2014 - "4-HNE could inhibit phosphatase and tensin homolog (PTEN) activity in hepatocytes and increased levels have been found in human invasive breast cancer. " 01/01/2014 - "MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN)."
4.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2015 - "The aim of this study was to determine a role of microRNA-21 (miRNA-21) in colorectal cancer (CRC) and to elucidate miRNA-21 regulation of hTERT by phosphatase and tensin homologue (PTEN). " 06/13/2014 - "The aim of the study was to identify expressions of Notch-1, microRNA-21 (miR-21), and phosphatase and tensin homolog (PTEN) in colorectal cancer (CRC), and to explore their relationship with clinical stages and metastatic status of CRC. " 01/01/2013 - "The aim of this study was to determine a role of microRNA-21 (miR-21) in colorectal cancer (CRC) and to elucidate the regulation of phosphatase and tensin homologue (PTEN) gene by miR-21. " 01/01/2015 - "A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer." 12/01/2014 - "In addition miR-494 promoted invasion and migration in colorectal cancer cells, and miR-494 directly inhibited the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression by targeting its 3'-untranslated region (3'-UTR). "
5.	Neoplasm Metastasis (Metastasis) 06/01/2015 - "Whether the loss of expression of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is associated with lymphatic-related metastasis needs elucidation. " 02/14/2012 - "Phosphatase and tensin homologue located on chromosome 10 deletion was common in certain histological subtypes and especially homozygous deletion was associated with high-grade malignancy, lymph node metastases and unfavourable long-term prognosis (P<0.001). " 01/01/2011 - "Additional deregulated gene products in this circuit, such as the metastasis-suppressor phosphatase and tensin homologue (PTEN; repressed by Snail) and the putative-metastasis inducer Yin Yang (YY) 1 (target of NF-κB) also have been associated in the regulation of EMT. " 06/08/2010 - "In a multivariate analysis, expression of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was significantly related to worse locoregional control (LRC; HR: 2.2, 95% CI: 1.1-4.6; P=0.03), independent of lymph node metastases (HR: 5.6, 95% CI: 1.2-27.4; P=0.03) and extranodal spread (HR: 2.7; 95% CI: 1.2-6.5; P=0.02). " 05/01/2014 - "Patients harboring phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations or phosphatase and tensin homolog loss, and those with more than two sites of metastasis who received more than one prior systemic chemotherapy before the referral had median PFS of 6.7 and 1.8 months, and median OS of 12.6 and 2.9 months, respectively. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	cetuximab (Erbitux)
3.	Messenger RNA (mRNA)
4.	Insulin-Like Growth Factor I (IGF-1)
5.	Proteins (Proteins, Gene)
6.	Caspase 3 (Caspase-3)
7.	Ribonucleotide Reductases (Ribonucleotide Reductase)
8.	Monoclonal Antibodies
9.	Matrix Metalloproteinase 14 (MT1-MMP)
10.	Levonorgestrel (Plan B)

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Brachytherapy
5.	Radiotherapy