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2,2-dimethyl-3-hydroxybutyric acid

structure given in first source; a urinary metabolite of simvastatin

Also Known As:

2,2-dimethyl-3-hydroxybutanoic acid; DMHB

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybutyrates: 6
      - 2,2-dimethyl-3-hydroxybutyric acid: 3
  - Acyclic Acids
    - Butyrates: 2613
      - Hydroxybutyrates: 6
        2,2-dimethyl-3-hydroxybutyric acid: 3
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Butyrates: 2613
      - Hydroxybutyrates: 6
        2,2-dimethyl-3-hydroxybutyric acid: 3

Experts

1.	Galvin, Christopher: 1 article (12/2016)
2.	Koppensteiner, Peter: 1 article (12/2016)
3.	Ninan, Ipe: 1 article (12/2016)
4.	Gu, Ying: 1 article (05/2010)
5.	Qiu, Haixia: 1 article (05/2010)
6.	Song, Liming: 1 article (05/2010)
7.	Xie, Jie: 1 article (05/2010)
8.	Zhang, Yang: 1 article (05/2010)
9.	Zhao, Jingquan: 1 article (05/2010)

Related Diseases

1.	Shock 12/01/2016 - "We observed a suppression of the excitability of dMHb neurons in mice that either underwent fear conditioning or were exposed to foot shock. " 12/01/2016 - "Given the potential role of the dMHb in aversive behaviors, we examined whether fear conditioning or exposure to foot shock affects excitability in dMHb neurons. "
2.	Fibrosis (Cirrhosis) 01/01/1976 - "Whereas in normal subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg within 3 hours after taking a 400 mg dose, in patients with liver cell failure, the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis."
3.	Breast Neoplasms (Breast Cancer) 05/01/2010 - "Most importantly, DMHB was not only readily soluble, allowing preparation of an intravenous injection solution at a clinically acceptable concentration, but it was also more photodynamic therapy (PDT) active to human breast carcinoma MCF-7 cells than its parent HB under irradiation. "

Related Drugs and Biologics

1.	Solutions
2.	1-phenyl-3,3-dimethyltriazene (PDT)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Intravenous Injections