MS 8209

an amphotericin B derivative with antifungal and antiviral properties; inhibits HIV-1 replication; prevents membrane expression of HIV-1 large envelope glycoprotein gp120; tested against scrapie

Also Known As:

1-deoxy-1-amino-4,6-O-benzylidene-fructosyl-amphotericin B; Amphotericin B, N-(1-deoxy-4,6-O-(phenylmethylene)-D-fructos-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1); MS-8209

Networked: 12 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Amphotericin B: 6619
        MS 8209: 12

Experts

1.	Adjou, K T: 3 articles (06/2000 - 01/2000)
2.	Dormont, D: 3 articles (06/2000 - 01/2000)
3.	Deslys, Jean-Philippe: 2 articles (06/2008 - 06/2002)
4.	Dormont, Dominique: 2 articles (06/2008 - 06/2002)
5.	Seman, Michel: 2 articles (06/2008 - 06/2002)
6.	Beringue, V: 2 articles (06/2000 - 02/2000)
7.	Deslys, J P: 2 articles (06/2000 - 01/2000)
8.	Seman, M: 2 articles (02/2000 - 01/2000)
9.	Adjou, Karim Tarik: 1 article (06/2008)
10.	Aumond, Pascal: 1 article (06/2008)

Related Diseases

1.	Scrapie 06/01/2002 - "To explore the MS-8209 effect at the cellular level, we investigated at the light and electron microscopy levels, the sequential appearance and distribution of PrP concurrently with histopathological changes in hamsters that were infected intracerebrally with the 263 K scrapie strain and treated or not with the drug. " 09/01/1994 - "Results indicate that MS-8209 was as efficient as AmB in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. " 09/01/1994 - "We report here on data obtained after treatment with AmB and one of its derivatives, MS-8209, in experimental scrapie of mouse and hamster. " 09/01/1994 - "Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie." 06/01/2002 - "Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters."
2.	Pneumonia (Pneumonitis) 12/01/1992 - "MS-8209 was the most effective agent for increasing the survival time in cryptococcal meningoencephalitis and for reducing CFU counts in spleen, brain, and lung during both cryptococcal pneumonia and meningoencephalitis. "
3.	Meningoencephalitis 12/01/1992 - "MS-8209 was the most effective agent for increasing the survival time in cryptococcal meningoencephalitis and for reducing CFU counts in spleen, brain, and lung during both cryptococcal pneumonia and meningoencephalitis. "
4.	Cryptococcosis 12/01/1992 - "Therapeutic efficacy of MS-8209 was assessed in murine candidiasis, cryptococcosis, and aspergillosis. "
5.	Candidiasis (Moniliasis) 12/01/1992 - "In candidiasis, MS-8209 (15 mg/kg) significantly increased the survival time compared with D-AmB (0.5 mg/kg). " 12/01/1992 - "Therapeutic efficacy of MS-8209 was assessed in murine candidiasis, cryptococcosis, and aspergillosis. "

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	PrPSc Proteins
3.	Anti-Bacterial Agents (Antibiotics)
4.	Glial Fibrillary Acidic Protein
5.	Prion Proteins
6.	Endopeptidase K (Proteinase K)
7.	Macrolides
8.	Dextran Sulfate
9.	Selegiline (E250)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Treatment Delay
2.	Aftercare (After-Treatment)