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TEI 1324
inhibits endothelin-induced DNA synthesis in cultured vascular smooth muscle cells; structure given in first source
Also Known As:
TEI-1324; methyl 5-(7-hydroxy-6-(3-hydroxy-5-methyl-1-nonenyl)bicyclo(3.3.0)oct-2-en-3-yl)pentanoate; 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-5-methyl-1-nonenyl)-, methyl ester, (3aS-(3aalpha,5beta,6alpha(1E,3R*,5R*),6aalpha))-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins I: 108
Epoprostenol: 4670
TEI 1324: 1
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins I: 108
Epoprostenol: 4670
TEI 1324: 1
Related Diseases
1.
Mastocytoma
09/01/1991 - "
The prostacyclin (PGI2) analogues, TEI-9063 and its methyl ester, TEI-1324, have been compared with another stable analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells.
"
Related Drugs and Biologics
1.
Epoprostenol Receptors
2.
Iloprost (Ventavis)
3.
Thrombin
4.
Epoprostenol (Prostacyclin)
5.
Esters
6.
Adenylyl Cyclases (Adenylyl Cyclase)
7.
17,20-dimethylisocarbacyclin