aciculatin

structure given in first source; isolated from the plant Chrysopogon aciculatis

Also Known As:

8-(2,6-dideoxy-ribo-hexopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one sesquihydrate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 01/01/2012 - "This study is the first to prove that aciculatin induces cell death in human cancer cells and HCT116 mouse xenografts due to G1 arrest and subsequent apoptosis. " 01/01/2012 - "The anti-cancer activity and importance of p53 after aciculatin treatment were also confirmed in the HCT116 xenograft models. " 01/01/2012 - "Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. " 01/01/2012 - "Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo."
2.	Arthritis (Polyarthritis) 01/01/2012 - "Our results show that aciculatin inhibits IL-1β-stimulated G-CSF expression and the subsequent neutrophil differentiation, suggesting that it might have therapeutic potential for inflammatory arthritis."

1.	Granulocyte Colony-Stimulating Factor (G-CSF)