grandisin

structure given in first source; a lignan isolated from the bark of Cryptocarya crassinervia; RN given refers to ((2alpha,3beta,4alpha,5beta)-(-))-isomer

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kato, Massuo Jorge: 2 articles (12/2012 - 12/2009)
2.	Valadares, Marize C: 2 articles (01/2010 - 12/2009)
3.	Figueiredo, Maria Raquel: 1 article (02/2022)
4.	Guimarães, Elsie F: 1 article (02/2022)
5.	Kaplan, Maria Auxiliadora C: 1 article (02/2022)
6.	Mafud, Ana Carolina: 1 article (02/2022)
7.	Marques, André M: 1 article (02/2022)
8.	Mascarenhas, Yvonne Primerano: 1 article (02/2022)
9.	Ponte, Cristiano G: 1 article (02/2022)
10.	Provance, David William: 1 article (02/2022)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 12/01/2012 - "In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi. " 11/10/2017 - "Based on evidence that modification of a natural product may result in a more effective drug than the natural product itself, and using known neolignan inhibitors veraguensin 1 and grandisin 2 as templates to synthesise simpler analogues, remarkable anti-trypanosomal activity and selectivity were found for 3,5-dimethoxylated diaryl-furan 5c and 2,4-dimethoxylated diaryl-tetrahydrofuran 4e analogues with EC50 0.01 μM and EC50 0.75 μM, respectively, the former being 260-fold more potent than veraguensin 1 and 150-fold better than benznidazole, the current available drugs for Chagas disease treatment. "
2.	Vascular Diseases (Vascular Disease) 02/09/2022 - "tectoniifolium has the potential to serve as a renewable source of grandisin on a large scale and the potential to serve as template for development of new drugs for vascular diseases with emphasis on disorders related to endothelial disfunction."
3.	Rheumatic Diseases (Rheumatism) 01/01/2010 - "Grandisin (GRA) is present in several plant species from Brazil used in popular medicine for the treatment of disorders such as colic, inflammation, rheumatism, dyspepsia and liver dysfunction. "
4.	Liver Diseases (Liver Disease) 01/01/2010 - "Grandisin (GRA) is present in several plant species from Brazil used in popular medicine for the treatment of disorders such as colic, inflammation, rheumatism, dyspepsia and liver dysfunction. "
5.	Inflammation (Inflammations) 01/01/2010 - "Grandisin (GRA) is present in several plant species from Brazil used in popular medicine for the treatment of disorders such as colic, inflammation, rheumatism, dyspepsia and liver dysfunction. "

Related Drugs and Biologics

1.	Lignans
2.	tetrahydrofuran
3.	galgravin
4.	furan
5.	benzonidazole (benznidazole)