pediocin PA-1

from Pediococcus acidilactici PAC-1.0; a 4.6 kDa peptide with 44 amino acids; exhibits antibacterial activity against several gram-positive bacterial strains; amino acid sequence given in first source

Also Known As:

Networked: 15 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fliss, Ismail: 2 articles (01/2021 - 08/2009)
2.	Hoffmann, Christian: 1 article (01/2022)
3.	Lacorte, Gustavo Augusto: 1 article (01/2022)
4.	Queiroz, Luciano Lopes: 1 article (01/2022)
5.	Todorov, Svetoslav Dimitrov: 1 article (01/2022)
6.	de Melo Franco, Bernadette Dora Gombossy: 1 article (01/2022)
7.	Biron, Eric: 1 article (01/2021)
8.	Boutin, Yvan: 1 article (01/2021)
9.	Buss, George P: 1 article (01/2021)
10.	Couture, Frédéric: 1 article (01/2021)

Related Diseases

1.	Infections 07/01/2004 - "A study of the prevalence, intensity and risk factors for soil-transmitted helminth infection was undertaken among school children aged 5-9 years attending a primary school in the fishing village in Peda Jalaripet, Visakhapatnam, South India. " 01/01/2022 - "Isolates identified as Pediococcus pentosaceus ST75BZ and Pediococcus pentosaceus ST87BZ contained operons encoding for bacteriocins pediocin PA-1 and penocin A, while isolate identified as Pediococcus acidilactici ST31BZ contained only the operon for pediocin PA-1 and a CRISPR/Cas system for protection against bacteriophage infection. " 02/27/2023 - "Pediocin PA-1 is a bacteriocin of recognized value with applications in food bio-preservation and the medical sector for the prevention of infection. "
2.	Hemolysis 01/01/2021 - "Besides, selected bacteriocins were not toxic to Caco-2 cells, and integrity of cell membrane was observed to remain unaffected in presence of these bacteriocins at concentrations up to 400 μg/mL. In hemolysis study, pediocin PA-1, bactofencin A, and nisin were observed to lyse rat erythrocytes at concentrations higher than 50 μg/mL, while microcin J25 showed no effect on these cells. "
3.	COVID-19 12/01/2023 - "Our study puts forth a preliminary information regarding potential utilization of food-grade LAB-derived bacteriocins, particularly Salivaricin B and Pediocin PA 1, for Covid-19 treatment and prophylaxis.Communicated"
4.	Foodborne Diseases 11/01/1996 - "Collectively, the data indicate that raw chicken treated with pediocin AcH exhibits antilisterial activity both before and after cooking, thus offering protection to consumers from foodborne illnesses caused by postprocessing recontamination and/or undercooking." 03/01/1993 - "Antibacterial efficiency of two bacteriocins from lactic acid bacteria, pediocin AcH, and nisin was tested individually and in combination against several gram-positive bacterial strains including some involved in food spoilage and foodborne diseases. "
5.	Body Weight (Weight, Body) 08/15/2009 - "acidilactici UL5 nor ingested purified pediocin PA-1 had any negative effect on feed intake or body weight development. " 04/01/1996 - "Estimation of the pharmacokinetic parameters in each drug was performed by Higuchi's Bayesian program, PEDA Pearson's correlation coefficient (r) between clearance and body weight was calculated for each drug. "

Related Drugs and Biologics

1.	Bacteriocins (Lantibiotics)
2.	Nisin
3.	salivaricin A
4.	microcin
5.	Vaccines
6.	Thromboplastin (Tissue Factor)
7.	Antibodies
8.	Boostrix
9.	chlorambucil-oleic acid conjugate
10.	typhoid Vi polysaccharide vaccine (Typhim Vi)