FR 110302

structure given in first source; a potent 5-lipoxygenase inhibitor

Also Known As:

2,2-dibutyl-5-(2-quinolylmethoxy)-1,2,3,4-tetrahydro-1-naphthol; FR-110302; FR110302; 1-Naphthalenol, 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthols: 64
        FR 110302: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthols: 64
      - FR 110302: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - FR 110302: 3

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/1992 - "FR110302 (10 mg/kg b.i.d.p.o.) significantly suppressed both of these indicators of asthma. " 07/01/1997 - "Many of these medications appear to be effective in the treatment of asthma (BAYX-1005; MK-0591; MK-886; AA-681; A-64077; ZD-2138; U-60257; FR-110302; BI-6239; A-78773; ABT-761; L-746530; L-699333; ZM-230487). "
2.	Respiratory Hypersensitivity 03/01/1993 - "These results suggest that FR110302 may be a useful drug for attenuating airway hyperresponsiveness in asthmatic patients." 03/01/1993 - "In the present study we examined the inhibitory effect of a potent 5-lipoxygenase inhibitor, FR110302, on airway hyperresponsiveness induced by ozone exposure in guinea pigs and dogs. " 03/01/1993 - "A 5-lipoxygenase inhibitor, FR110302, inhibits ozone-induced airway hyperresponsiveness in guinea pigs and dogs." 07/01/1992 - "A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats." 07/01/1992 - "To study the role of chemical mediators in airway hyperresponsiveness and simultaneous eosinophilia, we examined effects of a potent 5-lipoxygenase inhibitor FR110302 and those of prednisolone, indomethacin, platelet-activating factor (PAF) antagonist (RP-59227) and leukotriene C4 (LTC4) antagonist (ONO-1078) on airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles. "
3.	Eosinophilia 07/01/1992 - "A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats." 07/01/1992 - "To study the role of chemical mediators in airway hyperresponsiveness and simultaneous eosinophilia, we examined effects of a potent 5-lipoxygenase inhibitor FR110302 and those of prednisolone, indomethacin, platelet-activating factor (PAF) antagonist (RP-59227) and leukotriene C4 (LTC4) antagonist (ONO-1078) on airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles. "

Related Drugs and Biologics

1.	L 746530
2.	atreleuton
3.	ZM 230487
4.	L 699333
5.	A 78773
6.	MK 0591
7.	ICI D2138
8.	zileuton (Zyflo)
9.	MK-886
10.	piriprost