kinesin-II

Heterotrimeric kinesin-II is a plus end- directed microtubule (MT) motor protein consisting of distinct heterodimerized motor subunits associated with an accessory subunit

Also Known As:

kinase-related protein (kinesin II); kinesin II

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        Molecular Motor Proteins: 16
        Kinesins: 992
        kinesin-II: 10
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoskeletal Proteins: 739
    - Microtubule Proteins: 41
      - Microtubule-Associated Proteins: 3219
        Kinesins: 992
        kinesin-II: 10
  - Nerve Tissue Proteins: 2
    - Microtubule-Associated Proteins: 3219
      - Kinesins: 992
        kinesin-II: 10

Experts

1.	Ishida, Yamato: 1 article (01/2022)
2.	Katoh, Yohei: 1 article (01/2022)
3.	Nakayama, Kazuhisa: 1 article (01/2022)
4.	Tasaki, Koshi: 1 article (01/2022)
5.	Chang, Chia-Hsiang: 1 article (01/2019)
6.	Chen, Jia-Long: 1 article (01/2019)
7.	Tsai, Jin-Wu: 1 article (01/2019)
8.	DePaolo, John S: 1 article (04/2014)
9.	Guo, Jianhui: 1 article (04/2014)
10.	Li, Yingchun: 1 article (04/2014)

Related Diseases

1.	Ciliopathies 01/01/2022 - "Altogether these results indicate that impaired anterograde trafficking caused by a decrease in the ciliary level of IFT-B or in its binding to kinesin-II underlies the ciliary defects found in skeletal ciliopathies caused by IFT52 variations." 01/01/2019 - "Here, we first investigated the effects of ciliopathy on neural stem cells by knocking down Kif3a, a kinesin II motor required for ciliogenesis, in the neurogenic stage of cortical development by in utero electroporation of mouse embryos. "
2.	Ganglion Cysts (Ganglion) 03/01/2005 - "Double labelling for kinesin II demonstrates colocalization of bipolar cell ribbons at the sites of contact between these two types of ganglion cell and the line 357 bipolar cells."
3.	Stomach Neoplasms (Stomach Cancer) 04/02/2013 - "We examined preoperative kinesin II-associated protein (KAP1), TIMP metallopeptidase inhibitor 1 (TIMP1) and stanniocalcin 2 (STC2) expression levels in patients with gastric cancers to assess their clinical application for diagnosing and monitoring diseases. "
4.	Situs Inversus 04/27/1999 - "Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II."
5.	Short Rib-Polydactyly Syndrome 01/01/2022 - "We here show that IFT52 variants found in individuals with short-rib polydactyly syndrome (SRPS) are compromised in terms of formation of the IFT-B holocomplex from two subcomplexes and its interaction with heterotrimeric kinesin-II. IFT52-knockout (KO) cells expressing IFT52 variants that mimic the cellular conditions of individuals with SRPS demonstrated mild ciliogenesis defects and a decrease in ciliary IFT-B level. "

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