peptide 74

amino acid sequence given in first source; a synthetic peptide that contains the sequence immediately upstream of the cleavage site of the 72-kDa type IV collagenase and other members of the matrix metalloproteinase family; inhibits the activated form of this enzyme

Also Known As:

Thr-Met-Arg-Lys-Pro-Arg-Cys-Gly-Asn-Pro-Asp-Val-Ala-Asn; threonyl-methionyl-arginyl-lysyl-prolyl-arginyl-cysteinyl-glycyl-asparaginyl-prolyl-aspartyl-valyl-alanyl-asparagine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chang, Chien-Hsing: 1 article (03/2009)
2.	Goldenberg, David M: 1 article (03/2009)
3.	Johnson, Christine R: 1 article (03/2009)
4.	Karacay, Habibe: 1 article (03/2009)
5.	Litwin, Samuel: 1 article (03/2009)
6.	McBride, William J: 1 article (03/2009)
7.	Rossi, Edmund A: 1 article (03/2009)
8.	Sharkey, Robert M: 1 article (03/2009)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2009 - "Biodistribution data indicated that when unlabeled veltuzumab (1.0 or 0.25 mg) was administered in advance of the radiolabeled veltuzumab or bispecific antibody injection, tumor uptake was significantly reduced ((111)In-veltuzumab, 47% and 25%, respectively; (111)In-hapten-peptide, 74% and 49%, respectively). " 04/15/1992 - "Peptide 74 and the control peptide 78, which contains a single substitution of serine for the "critical" cysteine residue, were added at 30 microM concentrations to the upper compartment of the Boyden chamber in the chemoinvasion assay using HT1080 and A2058 human tumor cells. "
2.	Human Influenza (Influenza) 09/01/1992 - "The HIV-Nef7F peptide (74-82) was presented by HLA-A3 to Nef-specific HLA-A3-restricted CTL lines, and the influenza nucleoprotein peptide NP(380-393) was presented by HLA-B27 to NP(380-393)-specific HLA-B27-restricted CTL lines. "
3.	Infections 06/01/1990 - "Only CD4 peptide (74-95) and the shorter fragment (81-95) succeeded in protecting T cells against infection with different HIV-I strains. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/1994 - "Here we demonstrate that two specific inhibitors of MMP-2, TIMP-2 and a peptide from the MMP-2 propeptide region (peptide 74), inhibit endothelial cell invasion induced by AIDS-KS cell supernatants. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Tissue Inhibitor of Metalloproteinase-2
3.	HLA-B27 Antigen (HLA B27 Antigen)
4.	HLA-A3 Antigen (HLA A3 Antigen)
5.	Serine (L-Serine)
6.	Nucleoproteins
7.	Haptens
8.	Cysteine (L-Cysteine)
9.	veltuzumab
10.	peptide 78