integrin alphavbeta6

07/15/2009 - "Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model."
07/01/2009 - "In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery."
01/01/2023 - "This review focuses on the role of integrin Alpha v Beta 6 in cancer progression. "
10/15/2022 - "Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment."
09/01/2010 - "The integrin alphavbeta6 is expressed only on epithelia and then usually only during processes of tissue remodelling including cancer, where its high expression correlates with reduced survival. "

05/01/2008 - "Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease."
05/01/2008 - "Thus, alphavbeta6 integrin is constitutively expressed in the epithelium sealing the gingiva to the tooth and plays a central role in protection against inflammatory periodontal disease through activation of TGF-beta1."
05/01/2008 - "Moreover, expression of alphavbeta6 integrin was down-regulated in human periodontal disease, a common medical condition causing tooth loss and also contributing to the development of cardiovascular diseases by increasing the total systemic inflammatory burden. "
05/01/2008 - "Moreover, an antibody that blocks alphavbeta6 integrin-mediated activation of TGF-beta1 initiated inflammatory periodontal disease in a rat model of gingival inflammation. "

03/01/2010 - "We found alphavbeta6 integrin strongly upregulated in biliary fibrosis, but its expression in primary and secondary liver tumours is unknown. "
11/01/2007 - "Role of alphavbeta6 integrin in acute biliary fibrosis."
03/01/2008 - "(1) Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression. "
08/01/2008 - "Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression."
11/01/2007 - "The findings provide a rationale for the use of inhibitors of alphavbeta6 integrin or TGFbeta for down-regulating fibrosis in the setting of acute or ongoing biliary injury."

08/08/2008 - "In this study, we investigated the apoptosis and its related signal pathways to integrin alphavbeta6 in colon cancer cells. "
08/08/2008 - "We confirmed that integrin alphavbeta6 acted as an important role in inhibiting apoptosis in colon cancer cells, and the signaling involved the mitochondrial pathway."
08/08/2008 - "Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells."
05/01/2008 - "Integrin alpha v beta 6 (alpha v beta 6) is correlated with colon cancer progression. "
05/01/2008 - "Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver."

02/01/2008 - "Lung injury score and integrin alpha v beta 6 mRNA level were lower in HS than in H (p<0.01). "
04/01/2009 - "Activation of latent transforming growth factor beta (TGF-beta) by alphavbeta6 integrin is critical in the pathogenesis of lung injury and fibrosis. "
04/01/2009 - "Finally, we show that the expression levels of both the LPA2 receptor and alphavbeta6 integrin are up-regulated and are spatially and temporally associated following bleomycin-induced lung injury. "
04/01/2009 - "These studies demonstrate that LPA induces alphavbeta6 integrin-mediated TGF-beta activation in epithelial cells via LPA2, G alpha(q), RhoA, and Rho kinase, and that this pathway might be clinically relevant to the development of lung injury and fibrosis."