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hydnocarpin

structure given in first source; isolated from Hydnocarpus wightiana seeds

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Huang, Guozheng: 4 articles (07/2022 - 01/2016)
2.	Gao, Hang: 2 articles (07/2022 - 01/2021)
3.	Hong, Huanwu: 2 articles (07/2022 - 01/2021)
4.	Lou, Siyue: 2 articles (07/2022 - 01/2021)
5.	Tian, Shasha: 2 articles (07/2022 - 01/2021)
6.	Zhao, Huajun: 2 articles (07/2022 - 01/2021)
7.	Maihesuti, Liwaliding: 2 articles (01/2021 - 01/2021)
8.	Kinghorn, A Douglas: 2 articles (11/2013 - 03/2009)
9.	Pan, Li: 2 articles (11/2013 - 03/2009)
10.	Wang, Nina: 1 article (07/2022)

Related Diseases

1.	Triple Negative Breast Neoplasms 08/01/2023 - "This study aims to investigate the effect and mechanism of hydnocarpin(HC) in treating triple negative breast cancer(TNBC). " 08/01/2023 - "[Hydnocarpin inhibits malignant progression of triple negative breast cancer via CNOT4-mediated ubiquitination and degradation of YAP]."
2.	Neoplasms (Cancer) 01/01/2021 - "Structural Modification of Sylibin to Derivatives of Sylibin/Hydnocarpin D/Silandrin, and Evaluation of their Cytotoxicity against Cancer Cells." 01/01/2021 - "Hydnocarpin D (HD) is a bioactive flavonolignan compound that possesses promising anti-tumor activity, although the mechanism is not fully understood. " 02/15/2023 - "BAL and its constituents 3, (3-(3-Methyl-1-oxo-2-butenyl))1H indole (1) and hydnocarpin (2), as well as the reference compound, doxorubicin, had antiproliferative activity against 9 cancer cell lines. " 01/01/2021 - "Some of the amide derivatives of sylibin/hydnocarpin D /silandrin exhibited a remarkable inhibitory effect of proliferation on cancer cells compared to silybin. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2021 - "Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis." 11/01/2013 - "The potentiating action of the flavonolignan, (-)-hydnocarpin, in combination with vincristine was evaluated in the 697 acute lymphoblastic leukemia cell line and a P-gp-expressing variant, 697-R. " 11/01/2013 - "Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line."
4.	Acute Lung Injury 07/01/2022 - "Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway."
5.	Prostatic Neoplasms (Prostate Cancer) 04/02/2023 - "The structure-activity relationships among the four different core structures (including flavanonol-type flavonolignan (silibinin), flavone-type flavonolignan (hydnocarpin D), chalcone-type flavonolignan, and taxifolin (a flavonolignan precursor) indicate that 5,7,20-O-trimethylsilybins are the most promising scaffold to selectively suppress AR-positive LNCaP prostate cancer cell proliferation. "

Related Drugs and Biologics

1.	Silybin (Lagosa)
2.	Catenins
3.	Apigenin
4.	Flavonolignans
5.	Genistein
6.	Lignans
7.	Vincristine (Oncovin)
8.	Lipopolysaccharides
9.	Doxorubicin (Adriamycin)
10.	Chalcone (Benzalacetophenone)