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gadolinium ethoxybenzyl DTPA

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DTPA covalently linked to the lipoohilic ethoxybenzyl moiety; a contrast agent in MR imaging of hepatobiliary system

Also Known As:

Gd-EOB-DTPA; Primovist; gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanoic acid disodium salt; gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid; gadoxetic acid disodium

Networked: 257 relevant articles (12 outcomes, 40 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Murakami, Takamichi: 13 articles (02/2015 - 04/2007)
2.	Ito, Katsuyoshi: 11 articles (06/2015 - 03/2010)
3.	Matsui, Osamu: 10 articles (10/2015 - 03/2011)
4.	Kanki, Akihiko: 10 articles (06/2015 - 03/2010)
5.	Tamada, Tsutomu: 10 articles (06/2015 - 03/2010)
6.	Kudo, Masatoshi: 9 articles (10/2015 - 01/2009)
7.	Higaki, Atsushi: 9 articles (06/2015 - 12/2011)
8.	Okada, Masahiro: 8 articles (02/2015 - 04/2007)
9.	Higashi, Hiroki: 8 articles (10/2013 - 03/2010)
10.	Sato, Tomohiro: 7 articles (06/2015 - 12/2011)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 07/01/2012 - "Combining DW-MRI with Gd-EOB-DTPA-enhanced T(1) weighted MRI significantly improved the detection of colorectal liver metastases." 06/01/2015 - "This retrospective study was to investigate whether adding diffusion-weighted imaging (DWI) to Gd-EOB-DTPA-enhanced MRI (EOB-MRI) improved the detection of liver metastasis in radiology resident and board-certified radiologist groups. " 07/01/2012 - "Using combined image set improved identification of liver metastases compared with Gd-EOB-DTPA image set (p<0.001) or DW-MRI image set (p<0.001). " 02/01/2012 - "This study was performed to assess the role of retrospective PET-MRI fusion with Ga-68-DOTA(0)-Phe(1)-Tyr(3)-octreotide (Ga-68-DOTATOC) PET and Gd-EOB-DTPA MRI in the detection of hepatic metastases from neuroendocrine tumours (NET). " 05/01/2005 - "This study showed that interstitial MR lymphography with Gd-EOB-DTPA can detect metastasis and that the optimal dose in rabbits is 8 micromol Gd/kg as a subcutaneous application."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2012 - "Efficacy of fusion imaging combining sonography and hepatobiliary phase MRI with Gd-EOB-DTPA to detect small hepatocellular carcinoma." 12/01/2014 - "Magnetic resonance imaging with gadoxetic acid disodium for the detection of hepatocellular carcinoma: a meta-analysis of 18 studies." 11/01/2012 - "The purpose of this study was to elucidate the incidence and risk factors for the progression of hypointense nodules observed in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) of hypervascular hepatocellular carcinoma (HCC). " 12/01/2011 - "The aim of this study was to reveal the relationship between intratumoral uptake of gadoliniumethoxylbenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) of hepatocellular carcinoma (HCC) in the hepatobiliary phase and pathological features. " 10/01/2009 - "Based on published clinical trials and the experience of the attendees in the use of Gd-EOB-DTPA in liver imaging, a new simplified, non-invasive diagnostic algorithm was proposed that would be applicable to both Eastern and Western clinical practice in the evaluation of hepatocarcinogenesis and hepatocellular carcinoma. "
3.	Neoplasms (Cancer) 06/15/2007 - "The use of gadoxetic acid disodium, a hepatocyte-specific contrast agent with prolonged retention, is described as a method of improved assessment of the ablative margins relative to the tumor margins." 01/01/2011 - "Gd-EOB-DTPA-enhanced T1-weighted imaging is helpful in the detection of hepatic tumors in H-ras 12V TG mice." 12/01/2015 - "The aim of this study was to investigate the feasibility of ablative margin (AM) grading by magnetic resonance imaging (MRI) with Gd-EOB-DTPA administered prior to radiofrequency ablation (RFA), and to identify factors for achieving a sufficient AM and predictors for local tumor progression. " 09/01/2010 - "This study included nine patients with nine histopathologically proven HCCs (mean size, 1.9 cm) that consisted of two portions of a non-hypointense (Gd-EOB-DTPA uptake) and hypointense area (no Gd-EOB-DTPA uptake) in one tumor as depicted on hepatobiliary-phase MR images. " 07/07/2015 - "Gd-EOB-DTPA-enhanced MRI in one case clearly showed a low-signal tumor in the hepatobiliary phase, similar to what was seen by positron emission tomography-CT. "
4.	Liver Diseases (Liver Disease) 07/01/2015 - "Improved parenchymal liver enhancement with extended delay on Gd-EOB-DTPA-enhanced MRI in patients with parenchymal liver disease: associated clinical and imaging factors." 02/01/2011 - "The results of our study demonstrate that the presence of chronic liver disease significantly affects the signal intensity of the bile duct in Gd-EOB-DTPA-enhanced MR imaging. " 11/01/2010 - "The purpose of this study was to describe magnetic resonance (MR) findings of focal eosinophilic liver disease using gadoxetic acid (Gd-EOB-DTPA). " 07/01/1992 - "In this study, Gd-EOB-DTPA was evaluated in a rodent model of metastatic liver disease to measure both relative enhancement and lesion-to-liver contrast. " 10/01/2015 - "Gd-EOB-DTPA-enhanced MRI may provide a useful detection method for liver disease in patients with LC-PBC."
5.	Fibrosis (Cirrhosis) 01/01/2015 - "Strong correlations of the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/cirrhosis, classified using the Ishak scoring system, were observed. " 07/17/2014 - "Hepatocyte phase RCEI values obtained with Gd-EOB-DTPA-enhanced MRI scan indicate liver injury in hepatic fibrosis and early cirrhosis. " 07/17/2014 - "To evaluate the hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the early diagnosis of hepatic fibrosis and cirrhosis and assessment of liver function in a rat model. " 02/25/2014 - "Hepatobiliary phase imaging may improve the diagnostic confidence and sensitivity of GD-EOB-DTPA for HCC in cirrhosis." 06/01/2013 - "Primovist-enhanced MRI is very accurate in the identification of HCC in cirrhosis, especially if the tumour is greater than 17 mm and undifferentiated. "

Related Drugs and Biologics

1.	Gadolinium
2.	Pentetic Acid (DTPA)
3.	Intrahepatic cholangiocarcinoma
4.	Gadolinium DTPA (Magnevist)
5.	diethylenetriamine
6.	Acetic Acid (Vinegar)
7.	PENTA
8.	gadolinium ethoxybenzyl DTPA
9.	Contrast Media
10.	gadobenic acid (gadobenate dimeglumine)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Drug Therapy (Chemotherapy)
3.	Hepatectomy
4.	Intravenous Injections
5.	Catheters