HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
zelandopam
structure given in first source
Also Known As:
(-)-(S)-4-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline; 7,8-DDPTI; 7,8-dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline; YM 435; YM-435; YM435
Networked:
8
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Tetrahydroisoquinolines: 44
zelandopam: 8
Experts
1.
Aoki, Motonori
: 2 articles (03/2005 - 02/2003)
2.
Yatsu, Takeyuki
: 2 articles (03/2005 - 02/2003)
3.
Tanaka, Akihiro
: 1 article (03/2005)
4.
Inagaki, Osamu
: 1 article (02/2003)
Related Diseases
1.
Nephrosis
03/07/2005 - "
The present study demonstrates for the first time that zelandopam, a selective dopamine D1-like receptor agonist, is effective in blunting the development of PA-induced nephrosis, and that the effects of zelandopam are dose dependent.
"
03/07/2005 - "
Nephrosis was induced in rats with a single intravenous injection of PA at a dose of 50 mg/kg. The effects of zelandopam and prednisolone in PA nephrosis rats were evaluated before injection of PA and at 7 and 14 days after injection.
"
03/07/2005 - "
The present experiment was designed to investigate the role of peripheral dopamine D1-like receptors and to evaluate the prophylactic effect of zelandopam, a dopamine D1-like receptor agonist, on puromycin aminonucleoside (PA)-induced nephrosis in rats.
"
03/07/2005 - "
Effect of zelandopam, a dopamine D1-like receptor agonist, in puromycin aminonucleoside nephrosis rats.
"
2.
Atherosclerosis
11/01/1997 - "
To elucidate the role of vascular dopamine D1-like receptors in atherosclerosis, the effects of dopamine and specific D1-like agonists SKF 38,393 and YM 435 on platelet-derived growth factor (PDGF) BB-mediated VSMC migration and proliferation were studied.
"
01/01/1997 - "
To elucidate the role of vascular dopamine D1-like receptors in atherosclerosis, the effects of dopamine, specific D1-like agonists SKF 38,393, and YM 435 on platelet-derived growth factor (PDGF) BB-mediated VSMC migration, proliferation, and hypertrophy were studied.
"
04/01/1999 - "
To elucidate the role of vascular dopamine D1-like (D1 and D5) receptors in atherosclerosis, the effects of dopamine and the specific D1-like receptor agonists SKF 38393 and YM 435 on platelet-derived growth factor (PDGF)-BB-mediated VSMC migration, proliferation and hypertrophy were investigated.
"
3.
Hypertrophy
01/01/1997 - "
To elucidate the role of vascular dopamine D1-like receptors in atherosclerosis, the effects of dopamine, specific D1-like agonists SKF 38,393, and YM 435 on platelet-derived growth factor (PDGF) BB-mediated VSMC migration, proliferation, and hypertrophy were studied.
"
01/01/1997 - "
To elucidate the role of vascular D1-like receptors in VSMC hypertrophy, the effects of dopamine and specific D1-like receptor agonists SKF 38393 and YM 435 on platelet-derived growth factor (PDGF) BB-mediated VSMC hypertrophy was studied.
"
04/01/1999 - "
To elucidate the role of vascular dopamine D1-like (D1 and D5) receptors in atherosclerosis, the effects of dopamine and the specific D1-like receptor agonists SKF 38393 and YM 435 on platelet-derived growth factor (PDGF)-BB-mediated VSMC migration, proliferation and hypertrophy were investigated.
"
4.
Acute Kidney Injury (Acute Renal Failure)
11/01/1998 - "
1. The effects of (-)-(S)-4-(3,4-dihydroxyphenyl)- 1,2,3,4-tetrahydroisoquinoline-7,8-diol monohydrochloride monohydrate (YM435), a dopamine DA1 receptor agonist, were evaluated in a canine model of ischemic acute renal failure (ARF).
"
11/01/1998 - "
Effect of YM435, a dopamine DA1 receptor agonist, in a canine model of ischemic acute renal failure.
"
02/14/2003 - "
To elucidate the role of peripheral dopamine D1 receptors in cisplatin-induced acute renal injury, effect of zelandopam (YM435, (-)-(S)-4-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate), a selective renal dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats was studied.
"
02/14/2003 - "
Preventive effect of zelandopam, a dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats.
"
5.
Proteinuria
03/07/2005 - "
Zelandopam dose-dependently attenuated the increase in proteinuria and total cholesterol.
"
Related Drugs and Biologics
1.
Dopamine (Intropin)
2.
Platelet-Derived Growth Factor
3.
Becaplermin (PDGF-BB)
4.
2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)
5.
Dopamine D1 Receptors (Dopamine D1 Receptor)
6.
Sodium
7.
Puromycin Aminonucleoside
8.
Prednisolone (Predate)
9.
Cisplatin (Platino)
10.
Cholesterol
Related Therapies and Procedures
1.
Intravenous Infusions
2.
Intravenous Injections