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herpes simplex virus type 1 protein VP22

protein VP22 is encoded by gene UL49; has been sequenced

Also Known As:

HSV-1 VP22; HSV-1 protein UL49; HSV-1 protein VP22; VP22 protein, HSV-1; herpes simplex virus type 1 protein UL49

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Structural Proteins: 171
      - herpes simplex virus type 1 protein VP22: 5

Experts

1.	He, Liangmei: 2 articles (07/2004 - 03/2002)
2.	Hung, Chien-Fu: 2 articles (07/2004 - 03/2002)
3.	Wu, T-C: 2 articles (07/2004 - 03/2002)
4.	Chen, Shunhua: 1 article (01/2018)
5.	Huang, Jian: 1 article (01/2018)
6.	Li, Yangxin: 1 article (01/2018)
7.	Su, Chenhe: 1 article (01/2018)
8.	You, Hongjuan: 1 article (01/2018)
9.	Zheng, Chunfu: 1 article (01/2018)
10.	Li, Li-Wen: 1 article (02/2011)

Related Diseases

1.	Marek Disease (Marek's Disease) 03/01/2002 - "Recently, studies have demonstrated that the protein encoded by UL49 of Marek's disease virus type 1 (MDV-1) exhibits some degree of homology to the HSV-1 VP22 protein and features the property of intercellular transport. "
2.	Neoplasms (Cancer) 07/01/2004 - "A naked Sindbis RNA replicon vector (SINrep5) encoding the herpes simplex virus type 1 protein VP22 linked to E7 (SINrep5-VP22/E7) generated significant antitumor effects against TC-1 and TC-1 P3(A15), tumors with down-regulated MHC class I expression. " 02/01/2011 - "In this article, we postulate that cell-permeable, phosphorylation-defective 4E-BP fusion proteins, which could be prepared by substituting the mTOR recognition motif located in N-terminal of 4E-BPs with protein transduction domain from HIV-1 TAT, HSV-1 VP22 or PTD4, could not only inhibit tumor growth but also enhance tumor response to radiation therapy through disruption of eIF4F complex assembly. "
3.	Virus Diseases (Viral Diseases) 01/01/2018 - "In addition, stable knockdown of cGAS facilitated the replication of ΔVP22 virus but not the WT. In summary, our findings indicate that HSV-1 VP22 acts as an antagonist of IFN signaling to persistently evade host innate antiviral responses.IMPORTANCE cGAS is very important for host defense against viral infection, and many viruses have evolved ways to target cGAS and successfully evade the attack by the immune system of their susceptible host. "
4.	Infections 11/01/2001 - "Like HSV-1 VP22, HSV-2 VP22 is synthesized ca. 4 h after infection, and the isoform later incorporated into virions is hypophosphorylated. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Eukaryotic Initiation Factor-4F (EIF4F)
3.	Protein Isoforms (Isoforms)
4.	RNA (Ribonucleic Acid)
5.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Radiotherapy