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N 0861

adenosine receptor antagonist; structure given in first source

Also Known As:

N(6)-endonorbornan-2-yl-9-methyladenine; N-0861; N0861; 9H-Purin-6-amine, N-bicyclo(2.2.1)hept-2-yl-9-methyl-, endo-(+-)-

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Terpenes: 260
    - Monoterpenes: 97
      - Norbornanes
        N 0861: 9
Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Purines: 436
    - Adenine: 1702
      - N 0861: 9

Experts

1.	Kodani, E: 1 article (09/2001)
2.	Bolli, R: 1 article (09/2001)
3.	Tang, X L: 1 article (09/2001)
4.	Auchampach, J A: 1 article (09/2001)

Related Diseases

1.	Coronary Stenosis (Coronary Artery Stenosis) 02/01/1995 - "The goal of this study was to determine whether N-0861 has any crossover effect on the A2 vasodilatory action of adenosine or on 201TI uptake which would adversely affect imaging of coronary stenoses. " 02/01/1995 - "These data indicate that N-0861 pretreatment does not adversely affect adenosine A2 receptor-mediated vasodilation and has no effect on the detection of a critical coronary stenosis by 201Tl imaging. "
2.	Bradycardia 05/27/1992 - "The lowest i.v. dose of N-0861 to antagonize A1 receptor-mediated bradycardia was 0.3 mumol/kg i.v.; the duration of effect ranged from 1 min (following 0.3-1 mumol/kg) to approximately 2.5 h (following 10 mumol/kg). " 05/27/1992 - "The selectivity of antagonism of A1 vs. A2 receptors by N-0861 was evaluated by generating dose-response curves to adenosine-induced bradycardia (A1 effect), and vasodilation in the in situ constant-flow perfused rat hindquarter vasculature (A2 effect). " 05/01/1994 - "Selectivity of N-0861 for the adenosine A1 receptor may, without reducing coronary blood flow, ameliorate bradyarrhythmia and maintain the positive inotropic response when exogenous adenosine is given or when interstitial myocardial adenosine is increased."
3.	Anoxia (Hypoxia) 03/01/1992 - "N-0861 significantly reduced stimulus to His bundle prolongation induced by either hypoxia or reduced perfusion ("ischemia") but did not attenuate the hypoxia-induced decrease in coronary perfusion pressure. " 01/01/1993 - "Both N0861 and pertussis toxin treatment significantly reduced the degree of hypoxia induced AV nodal conduction block and delayed its appearance. " 01/01/1993 - "Animals subjected to 10 min periods of global hypoxia, induced by decremental changes in O2 content in the inhaled gas mixture, were randomly divided into three groups: group I = control; group II = animals treated with a new selective A1 adenosine receptor antagonist, N0861 (N6-endo-norbornan-2-yl-9-methyladenine); and group III-animals treated with pertussis toxin, an irreversible inhibitor of specific guanine nucleotide binding proteins (G protein). "
4.	Myocardial Stunning (Stunned Myocardium) 09/01/2001 - "Importantly, N-0861 did not influence the degree of myocardial stunning in the absence of PC (group II) and it did not block the development of late ischemic PC. "
5.	Ventricular Fibrillation 01/01/1993 - "N-0861 significantly enhanced immediate postdefibrillation electrophysiological and haemodynamic recovery compared to placebo for ventricular fibrillation episodes lasting 35 s. " 01/01/1993 - "Halothane-nitrous oxide anaesthetised Duroc pigs of either sex, weight 22-25 kg, were subjected to sequential episodes of induced ventricular fibrillation lasting either 15 s (terminated by a suprathreshold shock at 60-70 A) or 35 s (subjected to a subthreshold shock at 20 A followed by a suprathreshold shock at 60-70 A) during intravenous placebo infusion (n = 10), N-0861 infusion (0.1 mg.kg-1.min-1, n = 10), and N-0861 infusion plus propranolol (2 mg.kg-1, n = 6). "

Related Drugs and Biologics

1.	Adenosine
2.	Purinergic P1 Receptors (Adenosine Receptor)
3.	Adenosine A2 Receptors
4.	Adenosine A1 Receptor
5.	Pertussis Toxin
6.	GTP-Binding Proteins (G-Protein)
7.	Magnesium Chloride
8.	Verapamil (Calan)
9.	Propranolol (Inderal)
10.	Nitrous Oxide (Laughing Gas)