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fominoben

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was MH 1975-92 (see under MORPHOLINES 1975-90); use MORPHOLINES to search FOMINOBEN 1975-92

Also Known As:

Noleptan; PB-89; VNC-3

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Oxazines: 2
    - Morpholines: 4
      - fominoben: 16

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/1985 - "Effects of the antitussive fominoben (PB89) on hypoxia in chronic obstructive lung disease: comparison with dextromethorphan using a double-blind method." 09/01/1976 - "The substituted benzylamin-derivative fominoben (PB 89 Noleptan) was intravenously administered to 12 patients with chronic obstructive lung disease in order to determine, whether an analeptic action on respiration, which had been found by others in animal studies and in healthy subjects, can also be demonstrated in patients with COLD. "
2.	Cough 06/01/1986 - "The cough reflex was significantly inhibited by fominoben (5 mg/kg, i.v.) and dextromethorphan (3 mg/kg, i.v.). " 11/01/1982 - "After administration of dextromethorphan (10 mg/kg, i.v.) or fominoben (8 mg/kg, i.v.), the increase in power of the 2 approximately 100 Hz band components of the phrenic nerve activity during the cough reflex was decreased significantly for 5 approximately 10 min; however, the other frequency band components were not affected. " 09/01/1983 - "Eptazocine produced decreases in RA, NC and AC at 1 mg, and, additionally, RV at 10 mg. Fominoben increased RR, RA and RV dose-dependently at 0.3-3 mg, although it depressed NC and AC at 3 mg. These findings suggest that the thresholds for the cough responses and respiratory responses to antitussive drugs are different from drug to drug and that the respiratory centers and cough center in the brain stem are affected in a different manner even qualitatively." 09/01/1983 - "In order to understand the relationship between the cough and respiratory centers in the brain stem, we investigated the effects of antitussive drugs such as codeine, dextromethorphan, eptazocine and fominoben on respiratory movement and the cough reflex. "
3.	Seizures (Seizure) 07/01/1984 - "The anticonvulsant effects of fominoben were less pronounced against 3-MP-induced seizures. " 07/01/1984 - "Fominoben (50 and 100 mg/kg) completely protected mice from seizures induced by 50 mg/kg PTZ and elevated the seizure latency against 75 mg/kg of PTZ. " 01/27/1984 - "Fominoben, a centrally acting antitussive, has been shown recently to bind to the brain benzodiazepine binding site and to antagonize pentylenetetrazol-induced seizures. "
4.	Obstructive Lung Diseases (Obstructive Lung Disease) 01/01/1985 - "We studied the effects of a non-narcotic, centrally acting antitussive, fominoben (PB89), on hypoxia in sixty patients suffering from chronic obstructive lung diseases (COLD), utilizing a double-blind method and using the antitussive dextromethorphan as a reference drug. " 01/01/1978 - "Mechanics of breathing, gas exchange and pulmonary hemodynamics were investigated in 10 patients with chronic-obstructive lung diseases before and after treatment with oral doses of 160 mg 3'-chloro-2'-(N-methyl-N-[(morpholino-carbonyl)methyl]-aminomethyl)benzanilide hydrochloride (fominoben, Noleptan) and 300 mg oxyethyltheophylline given three times daily. "
5.	Emphysema 01/01/1979 - "[Measurement of global diffusion capacity for CO, membrane diffusion capacity for CO and capillary blood volume in patients with bronchial emphysema after fominoben HCl. " 03/01/1981 - "[Clinical observation of fominoben hydrochloride on its blood gas value influence in the patient with chronic bronchitis, emphysema and cor pulmonale (author's transl)]."

Related Drugs and Biologics

1.	fominoben
2.	Dextromethorphan (Levomethorphan)
3.	Oxygen
4.	benzanilide
5.	Pentylenetetrazole (Metrazol)
6.	Dihydrotachysterol (AT 10)
7.	Codeine (Codeine Phosphate)
8.	Carbon Monoxide
9.	Benzodiazepines
10.	Antitussive Agents (Antitussives)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)